PSAT1 and CEBPE

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PSAT1	CEBPE
Gene Name		phosphoserine aminotransferase 1	CCAAT/enhancer binding protein (C/EBP), epsilon
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleoplasm
	Molecular Function	O-phospho-L-serine:2-oxoglutarate Aminotransferase Activity Pyridoxal Phosphate Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	L-serine Biosynthetic Process Pyridoxine Biosynthetic Process Cellular Amino Acid Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process	Transcription, DNA-templated Phagocytosis Defense Response Macrophage Differentiation Cytokine Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Pathways		Serine biosynthesis Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives
Drugs		Pyridoxal Phosphate L-Glutamic Acid
Diseases
GWAS		Obesity-related traits ( 23251661) Visceral fat ( 22589738)	Acute lymphoblastic leukemia (childhood) ( 23512250 19684604)
Protein-Protein Interactions		4 interactors: APP CEBPE MAPK6 PSMD10	44 interactors: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TCEB2 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		29968	1053
HPRD ID		17918	02852
Ensembl ID		ENSG00000135069	ENSG00000092067
Uniprot IDs		Q9Y617	Q15744
PDB IDs		3E77	3T92
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Proteasome Regulatory Particle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cytoplasmic Sequestering Of NF-kappaB Neuron Remodeling Regulation Of Cellular Amino Acid Metabolic Process Proteasome Assembly Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process Immune System Process Protein Metabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Copper Ion Homeostasis Macrophage Differentiation Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Copper Ion Homeostasis Suckling Behavior Regulation Of Growth Cytokine Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Sequestering Of Protein Endocytosis Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cytokine Metabolic Process Negative Regulation Of Mitochondrion Organization Regulation Of Protein Kinase Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cellular Process Myeloid Cell Differentiation Hemopoiesis Myeloid Leukocyte Differentiation Cellular Metabolic Process Immune System Development Negative Regulation Of Cellular Metabolic Process Organ Development Dendritic Cell Differentiation Anatomical Structure Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity System Development Myeloid Dendritic Cell Differentiation Leukocyte Activation Myeloid Dendritic Cell Activation
Tagcloud ?		a4 aminotransferase brilliant caffeic calibrated cape coomassie deaminase densitometer gels glucosamine glyceraldehyde gnpda1 gpx guanine isomerase match myosin pdquest phenethyl phosphoserine psma1 psma4 sw480 synthetase tim triosephosphate tryptophanyl xviiib	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned
Tagcloud (Difference) ?		a4 aminotransferase brilliant caffeic calibrated cape coomassie deaminase densitometer gels glucosamine glyceraldehyde gnpda1 gpx guanine isomerase match myosin pdquest phenethyl phosphoserine psma1 psma4 sw480 synthetase tim triosephosphate tryptophanyl xviiib	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned
Tagcloud (Intersection) ?