PSAT1 and CEBPE

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PSAT1	CEBPE
Description		phosphoserine aminotransferase 1	CCAAT enhancer binding protein epsilon
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm Plasma Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	O-phospho-L-serine:2-oxoglutarate Aminotransferase Activity Protein Binding Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	L-serine Metabolic Process L-serine Biosynthetic Process Pyridoxine Biosynthetic Process Amino Acid Biosynthetic Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Defense Response Positive Regulation Of Gene Expression Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Integrated Stress Response Signaling
Pathways		Serine metabolism	Transcriptional regulation of granulopoiesis
Drugs		Pyridoxal phosphate Glutamic acid
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Daytime nap ( 33568662) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Visceral fat ( 22589738)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 29348612 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010 28158719 27863252)
Interacting Genes		5 interacting genes: APP CDC42 CEBPE MAPK6 PSMD10	45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		29968	1053
HPRD ID		17918	02852
Ensembl ID		ENSG00000135069	ENSG00000092067
Uniprot IDs		Q9Y617	Q15744
PDB IDs		3E77 8A5V 8A5W	3T92
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Endocytosis Regulation Of Postsynapse Organization Import Into Cell Postsynapse Phagocytosis, Engulfment Neuron Projection Organization Intracellular Signal Transduction Regulation Of Synapse Organization Macrophage Differentiation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination Positive Regulation Of Cell Cycle Regulation Of Substrate Adhesion-dependent Cell Spreading Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Vesicle-mediated Transport Phagocytosis Integrin-mediated Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Lipoprotein Particle Positive Regulation Of Locomotion Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of MAPK Cascade Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Positive Regulation Of Cell-substrate Adhesion Storage Vacuole Septin Cytoskeleton Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Regulatory Particle Assembly Myeloid Leukocyte Differentiation Regulation Of Synapse Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-binding Transcription Factor Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?