PSAT1 and PSMD10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PSAT1	PSMD10
Description		phosphoserine aminotransferase 1	proteasome 26S subunit, non-ATPase 10
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Proteasome Complex Nucleus Cytoplasm Cytosol Cytoskeleton Cilium Proteasome Regulatory Particle, Base Subcomplex Microtubule Cytoskeleton
	Molecular Function	O-phospho-L-serine:2-oxoglutarate Aminotransferase Activity Protein Binding Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	L-serine Metabolic Process L-serine Biosynthetic Process Pyridoxine Biosynthetic Process Amino Acid Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Cell Growth Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Regulatory Particle Assembly Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Serine metabolism	Proteasome assembly Proteasome assembly
Drugs		Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Daytime nap ( 33568662) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Visceral fat ( 22589738)
Interacting Genes		5 interacting genes: APP CDC42 CEBPE MAPK6 PSMD10	17 interacting genes: AGTR1 CCND2 CDK4 CEBPA CLIC1 GRSF1 HSPA4 LDB1 MAGEA4 MDM2 NCK2 NFKB1 PSAT1 PSMC4 RB1 RELA UBC
Entrez ID		29968	5716
HPRD ID		17918	04594
Ensembl ID		ENSG00000135069	ENSG00000101843
Uniprot IDs		Q9Y617	O75832
PDB IDs		3E77 8A5V 8A5W	1QYM 1TR4 1UOH 4NIK 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 7VO6 7VXV 7VXW 7VY4 7VY7
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Endocytosis Regulation Of Postsynapse Organization Import Into Cell Postsynapse Phagocytosis, Engulfment Neuron Projection Organization Intracellular Signal Transduction Regulation Of Synapse Organization Macrophage Differentiation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination Positive Regulation Of Cell Cycle Regulation Of Substrate Adhesion-dependent Cell Spreading Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Vesicle-mediated Transport Phagocytosis Integrin-mediated Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Lipoprotein Particle Positive Regulation Of Locomotion Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of MAPK Cascade Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Positive Regulation Of Cell-substrate Adhesion Storage Vacuole Septin Cytoskeleton Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Regulatory Particle Assembly Myeloid Leukocyte Differentiation Regulation Of Synapse Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Transcription Regulator Complex NF-kappaB P50/p65 Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Rb-E2F Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Cellular Response To Peptide Hormone Stimulus Cellular Response To Nicotine Regulation Of Inflammatory Response Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Cell Differentiation Response To Vitamin Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Initiation Regulation Of Cell Population Proliferation Actinin Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Population Proliferation Response To Interleukin-6 Positive Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone Response To Ether Response To Tumor Necrosis Factor Regulation Of Apoptotic Process Nucleoplasm Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Histone Deacetylase Binding
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