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ANAPC2 and ANAPC5
Number of citations of the paper that reports this interaction (PMID
12956947
)
61
Data Source:
BioGRID
(affinity chromatography technology, pull down, biochemical)
ANAPC2
ANAPC5
Gene Name
anaphase promoting complex subunit 2
anaphase promoting complex subunit 5
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Ubiquitin Protein Ligase Binding
Protein Phosphatase Binding
Biological Process
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Synaptic Plasticity
Positive Regulation Of Axon Extension
Positive Regulation Of Dendrite Morphogenesis
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Positive Regulation Of Synapse Maturation
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Pathways
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
13 interactors:
ANAPC11
ANAPC5
ANAPC7
CDC20
CDC26
CDC27
FBXO5
FZR1
MAD2L1
SMAD2
UBE2C
UBE2S
UFD1L
14 interactors:
ANAPC2
ANAPC4
BACH1
CDC20
CREBBP
FBXO5
FZR1
MAPK6
PABPC1
SMURF1
SMURF2
TGFBR1
UBE2S
ZBTB16
Entrez ID
29882
51433
HPRD ID
07367
10453
Ensembl ID
ENSG00000176248
ENSG00000089053
Uniprot IDs
B4DGH7
Q9UJX6
B4DFK4
F5H0F9
Q9UJX4
PDB IDs
Enriched GO Terms of Interacting Partners
?
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Mitotic Sister Chromatid Separation
Protein K11-linked Ubiquitination
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Cellular Protein Catabolic Process
Spindle Assembly Checkpoint
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Mitotic Spindle Checkpoint
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Chromosome Segregation
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Mitotic Nuclear Division
Spindle Checkpoint
Negative Regulation Of Mitotic Nuclear Division
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Mitotic Metaphase/anaphase Transition
Cellular Protein Catabolic Process
Negative Regulation Of Protein Catabolic Process
Protein Catabolic Process
Regulation Of Mitotic Nuclear Division
Cell Division
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Division
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Transferase Activity
Negative Regulation Of Chromosome Organization
Cellular Macromolecule Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Chromosome Organization
Positive Regulation Of Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Modification-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Cellular Macromolecule Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Protein Ubiquitination
Cellular Protein Metabolic Process
Activation Of Anaphase-promoting Complex Activity
Positive Regulation Of Cellular Metabolic Process
Cell Cycle
Positive Regulation Of Transferase Activity
Mitotic Nuclear Division
Regulation Of Mitotic Sister Chromatid Separation
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Cell Cycle Process
Protein Polyubiquitination
Mitotic Cell Cycle Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Protein Metabolic Process
Cellular Protein Modification Process
Mitotic Cell Cycle
Negative Regulation Of Cellular Protein Catabolic Process
Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Tagcloud
?
atl
bortezomib
cdc37
cobalt
exhibiting
faf1
fas
folding
heme
hif
hmox
hspa1a
hspa1b
hspca
htlv
instead
lethal
leukaemia
mt
neoplasia
oligonucleotide
oxygenase
pharmacologically
protoporphyrin
regimens
stabilisation
stip1
tay
urgently
Tagcloud (Difference)
?
atl
bortezomib
cdc37
cobalt
exhibiting
faf1
fas
folding
heme
hif
hmox
hspa1a
hspa1b
hspca
htlv
instead
lethal
leukaemia
mt
neoplasia
oligonucleotide
oxygenase
pharmacologically
protoporphyrin
regimens
stabilisation
stip1
tay
urgently
Tagcloud (Intersection)
?