ICOS and TNP1

		ICOS	TNP1
Description		inducible T cell costimulator	transition protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane	Nucleosome Male Germ Cell Nucleus Nucleus Chromosome
	Molecular Function	Protein Binding Signaling Receptor Activity	DNA Binding Protein Binding
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation T Follicular Helper Cell Differentiation Cell-cell Adhesion	Single Strand Break Repair Nucleosome Disassembly Chromatin Remodeling Spermatogenesis Spermatid Development Spermatid Nucleus Differentiation Spermatid Nucleus Elongation Positive Regulation Of Protein Processing Sexual Reproduction Cell Differentiation Flagellated Sperm Motility Heterochromatin Formation Sperm DNA Decondensation Sperm DNA Condensation Negative Regulation Of DNA-templated Transcription
Pathways		Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate ( 29403010) Height ( 25282103 31562340) Hypothyroidism ( 27182965) Mitral valve prolapse ( 26301497) Permanent tooth development ( 21931568) Pulse pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1	10 interacting genes: CSNK2A1 DVL3 PPARA PPARD PPARG PRKACA PRKACB PRKACG PRKCA SDCBP2
Entrez ID		29851	7141
HPRD ID		09196	01830
Ensembl ID		ENSG00000163600	ENSG00000118245
Uniprot IDs		Q53QY6 Q9Y6W8	P09430 Q4ZG82
PDB IDs		6X4G 7JOO
Enriched GO Terms of Interacting Partners?		T Follicular Helper Cell Differentiation T Cell Differentiation Involved In Immune Response Regulation Of Activated T Cell Proliferation T-helper Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Sperm DNA Decondensation Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Zonula Adherens Assembly Cytoplasmic Stress Granule CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway	CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Storage CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Intracellular Signal Transduction Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Negative Regulation Of Lipid Storage Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Negative Regulation Of MiRNA Transcription Renal System Process Multicellular Organismal-level Water Homeostasis Cellular Response To Fluid Shear Stress Protein Serine Kinase Activity Regulation Of Biological Quality Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Small Molecule Metabolic Process Ciliary Base Response To Fluid Shear Stress Protein Serine/threonine Kinase Activity Regulation Of Lipid Storage Regulation Of Intracellular Signal Transduction Nuclear Receptor Activity Response To Nutrient Levels Signal Transduction Protein Kinase Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cardiac Muscle Hypertrophy Cellular Response To Stress Regulation Of Muscle System Process Positive Regulation Of Protein Transport Regulation Of MiRNA Transcription Cellular Response To Nutrient Levels Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of Insulin Secretion Regulation Of MiRNA Metabolic Process Regulation Of Body Fluid Levels Kinase Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Secretion By Cell Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Fatty Acid Metabolic Process
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