ERCC5

Description		ERCC excision repair 5, endonuclease
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Protein-containing Complex
	Molecular Function	Bubble DNA Binding RNA Polymerase II Complex Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Enzyme Activator Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair DNA Recombination DNA Damage Response Response To UV Response To UV-C Negative Regulation Of Apoptotic Process
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)
Interacting Genes		12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51
Entrez ID		2073
HPRD ID		00595
Ensembl ID		ENSG00000134899
Uniprot IDs		P28715
PDB IDs		5EKF 5EKG 6TUR 6TUS 6TUW 6TUX 6VBH
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair DNA Repair DNA Metabolic Process DNA Damage Response Nuclear Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Transcription Factor TFIIH Core Complex Cellular Response To Stress Transcription Factor TFIIH Holo Complex Damaged DNA Binding Lateral Element Response To Radiation Nucleobase-containing Compound Metabolic Process Regulation Of DNA Damage Checkpoint Mitotic Recombination-dependent Replication Fork Processing Response To X-ray Nucleoplasm Transcription By RNA Polymerase II Response To Stress Response To Ionizing Radiation Replication Fork Processing Response To UV Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Male Germ Cell Nucleus Response To Gamma Radiation DNA-templated Transcription DNA-templated Transcription Elongation Nucleus Regulation Of Cell Cycle Phase Transition Transcription Elongation By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of DNA Repair DNA Binding Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Transcription-coupled Nucleotide-excision Repair Positive Regulation Of DNA Metabolic Process DNA Repair Complex Telomere Maintenance Via Recombination Telomere Maintenance Apoptotic Signaling Pathway Response To Light Stimulus Chromosome ATP-dependent DNA Damage Sensor Activity RNA Polymerase Binding Mitotic Recombination
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