ERCC5 and NTHL1

Number of citations of the paper that reports this interaction (PubMedID 9927729)
0

Data Source:
HPRD (in vitro)

		ERCC5	NTHL1
Description		ERCC excision repair 5, endonuclease	nth like DNA glycosylase 1
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Protein-containing Complex	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Bubble DNA Binding RNA Polymerase II Complex Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Enzyme Activator Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity DNA Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair DNA Recombination DNA Damage Response Response To UV Response To UV-C Negative Regulation Of Apoptotic Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair DNA Damage Response Depyrimidination
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)	Adult body size ( 32376654) Longevity ( 20834067)
Interacting Genes		12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51	4 interacting genes: ERCC5 PCNA SRPK2 TP53
Entrez ID		2073	4913
HPRD ID		00595	04039
Ensembl ID		ENSG00000134899	ENSG00000065057
Uniprot IDs		P28715	E5KTI5 P78549
PDB IDs		5EKF 5EKG 6TUR 6TUS 6TUW 6TUX 6VBH	7RDS 7RDT
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair DNA Repair DNA Metabolic Process DNA Damage Response Nuclear Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Transcription Factor TFIIH Core Complex Cellular Response To Stress Transcription Factor TFIIH Holo Complex Damaged DNA Binding Lateral Element Response To Radiation Nucleobase-containing Compound Metabolic Process Regulation Of DNA Damage Checkpoint Mitotic Recombination-dependent Replication Fork Processing Response To X-ray Nucleoplasm Transcription By RNA Polymerase II Response To Stress Response To Ionizing Radiation Replication Fork Processing Response To UV Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Male Germ Cell Nucleus Response To Gamma Radiation DNA-templated Transcription DNA-templated Transcription Elongation Nucleus Regulation Of Cell Cycle Phase Transition Transcription Elongation By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of DNA Repair DNA Binding Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Transcription-coupled Nucleotide-excision Repair Positive Regulation Of DNA Metabolic Process DNA Repair Complex Telomere Maintenance Via Recombination Telomere Maintenance Apoptotic Signaling Pathway Response To Light Stimulus Chromosome ATP-dependent DNA Damage Sensor Activity RNA Polymerase Binding Mitotic Recombination	Response To UV Nucleotide-excision Repair Response To Light Stimulus Cellular Response To UV Response To Radiation Transcription-coupled Nucleotide-excision Repair Cellular Response To Light Stimulus Negative Regulation Of Mitophagy Response To UV-C Base-excision Repair, AP Site Formation DNA Repair Cellular Response To Radiation Response To Stress Replication Fork DNA Metabolic Process 14-3-3 Protein Binding DNA Damage Response Negative Regulation Of Macroautophagy Heart Development Nucleic Acid Metabolic Process Regulation Of Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Protein-containing Complex Binding Mitophagy Response To Oxidative Stress Receptor Tyrosine Kinase Binding Regulation Of Cell Cycle Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Damaged DNA Binding Positive Regulation Of Neuron Apoptotic Process Interferon-mediated Signaling Pathway Autophagy Of Mitochondrion PCNA Complex Replisome Metanephric Distal Tubule Morphogenesis Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Tetramerization Positive Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Amino Acid PCNA-p21 Complex
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