GSTA4 and GSTA2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		GSTA4	GSTA2
Description		glutathione S-transferase alpha 4	glutathione S-transferase alpha 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Protein Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Glutathione Transferase Activity Protein Binding Transferase Activity
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Epithelial Cell Differentiation
Pathways		Glutathione conjugation	Glutathione conjugation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Azathioprine ADME
Drugs		Glutathione	Glutathione Chloroquine Glutathione disulfide Deoxycholic acid
Diseases
GWAS		Arterial stiffness index ( 31235810) Epilepsy (remission after treatment) ( 23962720) Nose size ( 27182965) Staphylococcus aureus nasal carriage (intermittent) ( 26569114)	Apolipoprotein A1 levels ( 32203549) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver volume ( 34128465) Red cell distribution width ( 32888494) Triglyceride levels ( 30698716 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		5 interacting genes: CIMIP5 DRC4 GSTA2 LSM1 NTAQ1	3 interacting genes: GSTA1 GSTA4 GSTA5
Entrez ID		2941	2939
HPRD ID		06899	00709
Ensembl ID		ENSG00000170899	ENSG00000244067
Uniprot IDs		O15217	A0A140VKE2 A8K987 P09210
PDB IDs		1GUL 1GUM 3IK7	1AGS 2VCT 2WJU 4ACS
Enriched GO Terms of Interacting Partners?		Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity	Glutathione Transferase Activity Glutathione Metabolic Process Xenobiotic Metabolic Process Modified Amino Acid Metabolic Process Sulfur Compound Metabolic Process Transferase Activity Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Glutathione Derivative Biosynthetic Process Steroid Delta-isomerase Activity Response To Hydrogen Sulfide Cellular Response To Hydrogen Sulfide Post-embryonic Camera-type Eye Morphogenesis Vascular Endothelial Growth Factor Binding Positive Regulation Of Nitric Oxide Mediated Signal Transduction Endocardium Development Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Sorting Endosome Post-embryonic Eye Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Wound Healing Positive Regulation Of Mitochondrial Depolarization Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Bone Development Lymph Vessel Development Positive Regulation Of Membrane Depolarization Endothelium Development Positive Regulation Of Vasculogenesis Regulation Of CGMP-mediated Signaling Epithelial Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Vasculogenesis Angiogenesis Involved In Wound Healing Surfactant Homeostasis Vascular Endothelial Growth Factor Signaling Pathway Glutathione Peroxidase Activity Linoleic Acid Metabolic Process Positive Regulation Of Mitochondrial Fission Embryonic Hemopoiesis Regulation Of Mitochondrial Depolarization Mesenchymal Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Epithelial Cell Maturation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Mesenchymal Cell Proliferation Peroxidase Activity Fatty Acid Binding Regulation Of Mitochondrial Fission Cellular Response To Vascular Endothelial Growth Factor Stimulus
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