GSTA2 and GSTA1

Number of citations: 25 (PubMedID 1530570)
Data Source: HPRD (in vitro)

		GSTA2	GSTA1
Name		glutathione S-transferase alpha 2	glutathione S-transferase alpha 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Protein Binding Transferase Activity	Glutathione Transferase Activity Peroxidase Activity Glutathione Peroxidase Activity Steroid Delta-isomerase Activity Fatty Acid Binding Protein Binding Oxidoreductase Activity Transferase Activity Isomerase Activity
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Epithelial Cell Differentiation	Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Epithelial Cell Differentiation Linoleic Acid Metabolic Process Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process
Pathways		Glutathione conjugation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Azathioprine ADME	Glutathione conjugation Heme degradation Azathioprine ADME NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Glutathione Chloroquine Glutathione disulfide Deoxycholic acid	Glutathione S-Hydroxycysteine 2-Hydroxyethyl Disulfide N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine Glutathione sulfonic acid Glutathione disulfide S-benzylglutathione Deoxycholic acid S-Hexylglutathione Hypericin
GWAS		Apolipoprotein A1 levels ( 32203549 ) Estimated glomerular filtration rate ( 31152163 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Hemoglobin levels ( 32327693 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver volume ( 34128465 ) Red cell distribution width ( 32888494 ) Triglyceride levels ( 30698716 32203549 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Triglyceride levels ( 33339817 )
Interacting Genes		3 interacting genes: GSTA1 GSTA4 GSTA5	7 interacting genes: APP GSTA2 LSM3 PPP2CB RPAIN ST3GAL1 YWHAE
Entrez ID		2939	2938
HPRD ID		00709	00708
Ensembl ID		ENSG00000244067	ENSG00000243955
Uniprot IDs		A0A140VKE2 A8K987 P09210	A0A140VJK4 B7Z1F9 P08263
PDB IDs		1AGS 2VCT 2WJU 4ACS	1GSD 1GSE 1GSF 1GUH 1K3L 1K3O 1K3Y 1LBK 1PKW 1PKZ 1PL1 1PL2 1USB 1XWG 1YDK 2R3X 2R6K 3I69 3I6A 3IK9 3KTL 3L0H 3Q74 3U6V 3ZFB 3ZFL 4HJ2 5JCU 5LCZ 5LD0 6ATO 6ATP 6ATQ 6ATR 6YAW 7BIB 7BIC 8BHC 8BHE
GO Terms Enriched among Interactors		Glutathione Transferase Activity Glutathione Metabolic Process Xenobiotic Metabolic Process Modified Amino Acid Metabolic Process Sulfur Compound Metabolic Process Transferase Activity Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Glutathione Derivative Biosynthetic Process Steroid Delta-isomerase Activity Response To Hydrogen Sulfide Cellular Response To Hydrogen Sulfide Post-embryonic Camera-type Eye Morphogenesis Vascular Endothelial Growth Factor Binding Positive Regulation Of Nitric Oxide Mediated Signal Transduction Endocardium Development Positive Regulation Of CGMP-mediated Signaling Blood Vessel Endothelial Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Sorting Endosome Post-embryonic Eye Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Wound Healing Positive Regulation Of Mitochondrial Depolarization Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Bone Development Lymph Vessel Development Positive Regulation Of Membrane Depolarization Endothelium Development Positive Regulation Of Vasculogenesis Regulation Of CGMP-mediated Signaling Epithelial Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Vasculogenesis Angiogenesis Involved In Wound Healing Surfactant Homeostasis Vascular Endothelial Growth Factor Signaling Pathway Glutathione Peroxidase Activity Linoleic Acid Metabolic Process Positive Regulation Of Mitochondrial Fission Embryonic Hemopoiesis Regulation Of Mitochondrial Depolarization Mesenchymal Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Epithelial Cell Maturation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Mesenchymal Cell Proliferation Peroxidase Activity Fatty Acid Binding Regulation Of Mitochondrial Fission Cellular Response To Vascular Endothelial Growth Factor Stimulus	Response To Lead Ion Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Medial Cisterna Membrane Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Protein Sialylation Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase Golgi Trans Cisterna Membrane Memory B Cell Differentiation Regulation Of Heart Rate By Hormone U6 SnRNA 3'-end Binding Regulation Of Calcium Ion Transmembrane Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Transmembrane Transporter Binding Ganglioside Biosynthetic Process Via Lactosylceramide Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Lsm1-7-Pat1 Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly