GSTA1

Gene Name		glutathione S-transferase alpha 1
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Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Glutathione Transferase Activity
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process Metabolic Process Epithelial Cell Differentiation Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione S-Hydroxycysteine 2-Hydroxyethyl Disulfide N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine Glutathione Sulfonic Acid S-Benzyl-Glutathione S-Hexylglutathione
Diseases
GWAS
Protein-protein Interactions		7 interactors: APP GSTA2 LSM3 PPP2CB RPAIN ST3GAL1 YWHAE
Entrez ID		2938
HPRD ID		00708
Ensembl ID
Uniprot IDs		B7Z1F9 P08263
PDB IDs		1GSD 1GSE 1GSF 1GUH 1K3L 1K3O 1K3Y 1LBK 1PKW 1PKZ 1PL1 1PL2 1USB 1XWG 1YDK 2R3X 2R6K 3I69 3I6A 3IK9 3KTL 3L0H 3Q74 3U6V 3ZFB 3ZFL 4HJ2
Enriched GO Terms of Interacting Partners?
Tagcloud ?		antigen appear approximate bp constitutive contain detoxification downregulates element fragment glutathione gsta2 gstalpha ikaros includes missing named prb promoters repress repression require resemble sufficient sv40 tagr transferase transient weights