GSS and GSTZ1

Number of citations of the paper that reports this interaction (PubMedID 15173170)
0

Data Source:
HPRD (in vitro)

		GSS	GSTZ1
Description		glutathione synthetase	glutathione S-transferase zeta 1
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Glutathione Synthase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity Glutathione Binding Metal Ion Binding	Catalytic Activity Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Maleylacetoacetate Isomerase Activity Transferase Activity Isomerase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Amino Acid Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Nervous System Development Response To Cadmium Ion	L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Glutathione Metabolic Process Aromatic Amino Acid Metabolic Process Cellular Oxidant Detoxification Cellular Detoxification
Pathways		Glutathione synthesis and recycling Defective GSS causes GSS deficiency	Glutathione conjugation Regulation of pyruvate dehydrogenase (PDH) complex Tyrosine catabolism
Drugs		Glutathione Glycine Cysteine gamma-Glutamylcysteine Phosphoaminophosphonic Acid-Adenylate Ester Acetylcysteine Copper	Glutathione 1,4-Dithiothreitol Dichloroacetic acid Glycerin
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) QRS complex (Cornell) ( 27659466) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: GSTZ1 OGT TERF1	10 interacting genes: CLVS2 CRYAA GORASP2 GSS PLEKHG4 PPP1CC QARS1 TCP11 TRAF2 ZMYND12
Entrez ID		2937	2954
HPRD ID		03000	04785
Ensembl ID		ENSG00000100983	ENSG00000100577
Uniprot IDs		P48637 V9HWJ1	A0A0A0MR33 A0A0C4DFM0 G3V4T6 O43708
PDB IDs		2HGS 8FBZ	1FW1 8E8P
Enriched GO Terms of Interacting Partners?		Maleylacetoacetate Isomerase Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein O-acetylglucosaminyltransferase Activity L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Regulation Of Transcription By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose G-rich Strand Telomeric DNA Binding Regulation Of Protein-containing Complex Assembly Telomeric Loop Disassembly NSL Complex T-circle Formation Telomere Capping Tyrosine Metabolic Process DNA Binding, Bending Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity Glutathione Peroxidase Activity Aromatic Amino Acid Family Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Sin3-type Complex Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Protein Homodimerization Activity Glutathione Transferase Activity
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