GSS and GSTZ1

Number of citations of the paper that reports this interaction (PMID 15173170)
2

Data Source:
HPRD (in vitro)

		GSS	GSTZ1
Gene Name		glutathione synthetase	glutathione S-transferase zeta 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Mitochondrion Cytosol
	Molecular Function	Magnesium Ion Binding Glutathione Synthase Activity ATP Binding Glycine Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Maleylacetoacetate Isomerase Activity Protein Homodimerization Activity
	Biological Process	Cellular Amino Acid Metabolic Process Glutathione Biosynthetic Process Xenobiotic Metabolic Process Response To Oxidative Stress Nervous System Development Aging Response To Nutrient Levels Response To Tumor Necrosis Factor Response To Amino Acid Small Molecule Metabolic Process Response To Cadmium Ion Glutathione Derivative Biosynthetic Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Phenylalanine and tyrosine catabolism Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione Glycine L-Cysteine Gamma-Glutamylcysteine Adenosine-5\'-Diphosphate Phosphoaminophosphonic Acid-Adenylate Ester	Glutathione 1,4-Dithiothreitol
Diseases
GWAS		Hemostatic factors and hematological phenotypes ( 22443383)
Protein-Protein Interactions		2 interactors: GSTZ1 TERF1	2 interactors: GSS PPP1CC
Entrez ID		2937	2954
HPRD ID		03000	04785
Ensembl ID		ENSG00000100983	ENSG00000100577
Uniprot IDs		P48637	G3V4T6 O43708
PDB IDs		2HGS	1FW1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Tyrosine Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Tyrosine Metabolic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Glutathione Derivative Biosynthetic Process Regulation Of Microtubule Polymerization Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Aromatic Amino Acid Family Metabolic Process Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Glutathione Metabolic Process Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cellular Protein Catabolic Process Telomere Maintenance Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Polymerization	Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Peptide Biosynthetic Process Response To Cadmium Ion Glycogen Metabolic Process Glutathione Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To External Stimulus Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Amino Acid Small Molecule Metabolic Process Response To Tumor Necrosis Factor Response To Organic Substance Energy Reserve Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Xenobiotic Stimulus Cellular Lipid Catabolic Process Peptide Metabolic Process Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Carbohydrate Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lipid Catabolic Process Cellular Modified Amino Acid Metabolic Process Protein Dephosphorylation Cellular Amide Metabolic Process
Tagcloud ?		5mug 5nm ag agnps alt antibacterial astrocytes bv collagenous cxcl13 deposited glutathione ldlr marco microglial n2a nep neprilysin neural neuron neutralization notice obviously otherwise plaques progress silver synthetase take	abolishes acidosis alter australian biotransformation catabolic catalyses converts dca dichloroacetic egr1 extending fumarylacetoacetate glutathione halo haplotypes homeodomain isomerization lactic maleylacetoacetate myb pharmacokinetics polymorphisms prx2 snp snps therapeutically transferase zeta
Tagcloud (Difference) ?		5mug 5nm ag agnps alt antibacterial astrocytes bv collagenous cxcl13 deposited ldlr marco microglial n2a nep neprilysin neural neuron neutralization notice obviously otherwise plaques progress silver synthetase take	abolishes acidosis alter australian biotransformation catabolic catalyses converts dca dichloroacetic egr1 extending fumarylacetoacetate halo haplotypes homeodomain isomerization lactic maleylacetoacetate myb pharmacokinetics polymorphisms prx2 snp snps therapeutically transferase zeta
Tagcloud (Intersection) ?		glutathione