GSS

Description		glutathione synthetase
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Glutathione Synthase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity Glutathione Binding Metal Ion Binding
	Biological Process	Amino Acid Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Nervous System Development Response To Cadmium Ion
Pathways		Glutathione synthesis and recycling Defective GSS causes GSS deficiency
Drugs		Glutathione Glycine Cysteine gamma-Glutamylcysteine Phosphoaminophosphonic Acid-Adenylate Ester Acetylcysteine Copper
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) QRS complex (Cornell) ( 27659466) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: GSTZ1 OGT TERF1
Entrez ID		2937
HPRD ID		03000
Ensembl ID		ENSG00000100983
Uniprot IDs		P48637 V9HWJ1
PDB IDs		2HGS 8FBZ
Enriched GO Terms of Interacting Partners?		Maleylacetoacetate Isomerase Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein O-acetylglucosaminyltransferase Activity L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Regulation Of Transcription By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose G-rich Strand Telomeric DNA Binding Regulation Of Protein-containing Complex Assembly Telomeric Loop Disassembly NSL Complex T-circle Formation Telomere Capping Tyrosine Metabolic Process DNA Binding, Bending Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity Glutathione Peroxidase Activity Aromatic Amino Acid Family Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Sin3-type Complex Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Protein Homodimerization Activity Glutathione Transferase Activity
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