METTL5 and ZBTB5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		METTL5	ZBTB5
Description		methyltransferase 5, N6-adenosine	zinc finger and BTB domain containing 5
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleolus Cytosol Cell Projection Synapse Presynapse Postsynapse	Chromatin Nucleus
	Molecular Function	Nucleic Acid Binding Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity RRNA (adenine-N6-)-methyltransferase Activity Transferase Activity S-adenosyl-L-methionine Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	RRNA Processing RRNA Methylation Methylation Positive Regulation Of Translation Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Medial orbital frontal cortex volume ( 31530798)	Bipolar disorder ( 31043756) Daytime nap ( 33568662)
Interacting Genes		2 interacting genes: TRMT112 ZBTB5	17 interacting genes: BAG4 BCOR CCDC85B DCX EP300 JADE2 METTL5 NCOR1 NCOR2 PPARG PTPN5 RSPH1 SP1 ST3GAL3 SWAP70 TP53 ZBTB7B
Entrez ID		29081	9925
HPRD ID		13699	08829
Ensembl ID		ENSG00000138382	ENSG00000168795
Uniprot IDs		Q9NRN9	O15062 Q5T942
PDB IDs		6H2U 6H2V	9B9R
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamine Methylation TRNA Methyltransferase Activator Activity RRNA (guanine-N7)-methylation TRNA (m2G10) Methyltransferase Complex RNA (guanine-N7)-methylation Positive Regulation Of RRNA Processing RRNA Base Methylation Protein Methyltransferase Activity Regulation Of RRNA Processing RRNA Methylation Maturation Of LSU-rRNA RRNA Modification Protein Methylation TRNA Methylation Maturation Of SSU-rRNA Positive Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling RNA Methylation TRNA Modification	Histone Deacetylase Binding Rhythmic Process Transcription Repressor Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Transcription Coregulator Binding Nuclear Receptor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Carbohydrate Catabolic Process STAT Family Protein Binding Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Purine Nucleotide Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Host-mediated Activation Of Viral Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Small Molecule Metabolic Process Circadian Behavior Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Behavior Mononuclear Cell Differentiation Histone Acetyltransferase Complex Regulation Of Small Molecule Metabolic Process Regulation Of Ketone Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Circadian Rhythm Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Fat Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Host-mediated Perturbation Of Viral Transcription Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of Apoptotic Signaling Pathway DNA Binding T Cell Lineage Commitment Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Leukocyte Differentiation
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