ANPEP and TM4SF1

Number of citations of the paper that reports this interaction (PubMedID 15812828)
0

Data Source:
HPRD (in vitro, in vivo)

		ANPEP	TM4SF1
Description		alanyl aminopeptidase, membrane	transmembrane 4 L six family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Lysosomal Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Aminopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Alanyl Aminopeptidase Activity Hydrolase Activity Signaling Receptor Activity Metal Ion Binding Metalloaminopeptidase Activity	Protein Binding
	Biological Process	Angiogenesis Angiotensin Maturation Proteolysis Cell Differentiation Peptide Catabolic Process Symbiont Entry Into Host Cell	Blastocyst Formation
Pathways		Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs		Ezetimibe Icatibant
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Gallstone disease ( 30504769) Intraocular pressure ( 29617998) Liver enzyme levels (alanine transaminase) ( 33972514)	Alanine aminotransferase levels ( 33547301)
Interacting Genes		2 interacting genes: MTDH TM4SF1	7 interacting genes: ANPEP DDR1 DNAJA1 HSPA8 SDCBP2 SLC13A1 TUBA4A
Entrez ID		290	4071
HPRD ID		01055	01854
Ensembl ID		ENSG00000166825	ENSG00000169908
Uniprot IDs		P15144 Q59E93	F8WF27 P30408
PDB IDs		4FYQ 4FYR 4FYS 4FYT 5LHD 6ATK 6U7E 6U7F 6U7G 6XWD 7AEW 7VPQ 8WDE
Enriched GO Terms of Interacting Partners?			C3HC4-type RING Finger Domain Binding Extracellular Exosome ATPase Activator Activity MHC Class II Protein Complex Binding Protein Refolding Protein-macromolecule Adaptor Activity Alanyl Aminopeptidase Activity Protein Transport Into Plasma Membrane Raft Smooth Muscle Cell-matrix Adhesion Protein Tyrosine Kinase Collagen Receptor Activity Response To Unfolded Protein G Protein-coupled Receptor Binding Heat Shock Protein Binding Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Enzyme Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Lumenal Side Of Lysosomal Membrane Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K8ac Reader Activity Histone H4K12ac Reader Activity Protein-folding Chaperone Binding Unfolded Protein Binding Regulation Of Protein Import Negative Regulation Of DNA Damage Checkpoint Histone H3K27ac Reader Activity Sodium Ion Transmembrane Transport Protein Transport Into Membrane Raft Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy P-TEFb Complex Binding Histone H4 Reader Activity Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Clathrin Coat Disassembly Histone H4K16ac Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane P-type Sodium:potassium-exchanging Transporter Activity ATP Metabolic Process Sodium Ion Transport Regulation Of Potassium Ion Import Negative Regulation Of JUN Kinase Activity Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Chaperone-mediated Autophagy Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Secondary Active Sulfate Transmembrane Transporter Activity RNA Polymerase II C-terminal Domain Binding
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