GPC5

Gene Name		glypican 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane Lysosomal Lumen
	Molecular Function	Heparan Sulfate Proteoglycan Binding
	Biological Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Hedgehog ligand biogenesis Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Release of Hh-Np from the secreting cell Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Processing-defective Hh variants abrogate ligand secretion MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Signaling by Hedgehog MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Height ( 20881960 20189936) HIV-1 control ( 20205591) Lung cancer ( 20304703) Metabolite levels ( 19043545) Multiple sclerosis ( 19010793) Nephrotic syndrome (acquired) ( 21441931) Obesity-related traits ( 23251661) Tetralogy of Fallot ( 23297363)
Protein-protein Interactions		1 interactors: DCPS
Entrez ID		2262
HPRD ID		03902
Ensembl ID		ENSG00000179399
Uniprot IDs		P78333
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Menadione Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Cis Splicing, Via Spliceosome Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing Aromatic Compound Catabolic Process
Tagcloud ?		12q13 alteration alveolar arises arms armss classically considerably copy ddit3 dicer embryonal foxo1 fusing fusion gains gli1 glypican highlights lrp1b moderately mycn pax3 pax7 q14 q35 rearrangement rhabdomyosarcoma wnt6