GPC5 and DCPS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GPC5	DCPS
Gene Name		glypican 5	decapping enzyme, scavenger
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane Lysosomal Lumen	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Heparan Sulfate Proteoglycan Binding	RNA 7-methylguanosine Cap Binding Protein Binding M7G(5')pppN Diphosphatase Activity
	Biological Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Gene Expression Cellular Response To Menadione Negative Regulation Of Programmed Cell Death Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay MRNA Cis Splicing, Via Spliceosome
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Hedgehog ligand biogenesis Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Release of Hh-Np from the secreting cell Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Processing-defective Hh variants abrogate ligand secretion MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Signaling by Hedgehog MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	mRNA decay by 3' to 5' exoribonuclease Deadenylation-dependent mRNA decay
Drugs			7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5\'-Diphosphate N7-Methyl-Guanosine-5\'-Monophosphate Mrna Cap Analog N7-Methyl Gpppg 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Height ( 20881960 20189936) HIV-1 control ( 20205591) Lung cancer ( 20304703) Metabolite levels ( 19043545) Multiple sclerosis ( 19010793) Nephrotic syndrome (acquired) ( 21441931) Obesity-related traits ( 23251661) Tetralogy of Fallot ( 23297363)
Protein-Protein Interactions		1 interactors: DCPS	6 interactors: ANAPC10 CDC27 CHST4 CSNK2A2 GPC5 YWHAQ
Entrez ID		2262	28960
HPRD ID		03902	16787
Ensembl ID		ENSG00000179399	ENSG00000110063
Uniprot IDs		P78333	Q96C86
PDB IDs			1ST0 1ST4 1XML 1XMM 3BL7 3BL9 3BLA
Enriched GO Terms of Interacting Partners?		Cellular Response To Menadione Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Cis Splicing, Via Spliceosome Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing Aromatic Compound Catabolic Process	Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Division Mitotic Spindle Assembly Checkpoint Regulation Of Organelle Organization Spindle Assembly Checkpoint Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Proteolysis Mitotic Cell Cycle Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		12q13 alteration alveolar arises arms armss classically considerably copy ddit3 dicer embryonal foxo1 fusing fusion gains gli1 glypican highlights lrp1b moderately mycn pax3 pax7 q14 q35 rearrangement rhabdomyosarcoma wnt6	alongside amazon biblica communities del dental dentists globally hope illustrates jungle otherwise peru peruvian programme project restorative river scope serves service sustainable transferable tributaries trust uk union vine volunteer
Tagcloud (Difference) ?		12q13 alteration alveolar arises arms armss classically considerably copy ddit3 dicer embryonal foxo1 fusing fusion gains gli1 glypican highlights lrp1b moderately mycn pax3 pax7 q14 q35 rearrangement rhabdomyosarcoma wnt6	alongside amazon biblica communities del dental dentists globally hope illustrates jungle otherwise peru peruvian programme project restorative river scope serves service sustainable transferable tributaries trust uk union vine volunteer
Tagcloud (Intersection) ?