CACNB1

Description		calcium voltage-gated channel auxiliary subunit beta 1
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane T-tubule Monoatomic Ion Channel Complex Sarcolemma Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Positive Regulation Of Muscle Contraction Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Cellular Response To Amyloid-beta
Pathways		Presynaptic depolarization and calcium channel opening NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Ibutilide Amlodipine Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Azelnidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Asthma ( 31619474) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377)
Interacting Genes		8 interacting genes: APP ATN1 CACNA1A CTBP2 DYNLL1 NEDD4L REM1 SRPK1
Entrez ID		782
HPRD ID		11743
Ensembl ID		ENSG00000067191
Uniprot IDs		Q02641
PDB IDs		7VFS 7VFU 7VFV 7VFW 7XLQ 7YG5
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Amyloid-beta Regulation Of Metal Ion Transport Regulation Of Nitric Oxide Metabolic Process Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Monoatomic Ion Transport Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Inorganic Cation Import Across Plasma Membrane Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Nuclear Matrix Transmembrane Transporter Binding Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Calcium Ion Transmembrane Transport Central Nervous System Development Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation
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