CLIC5 and GSN

Number of citations of the paper that reports this interaction (PubMedID 10793131)
42

Data Source:
HPRD (in vitro)

		CLIC5	GSN
Description		chloride intracellular channel 5	gelsolin
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Stereocilium Monoatomic Ion Channel Complex Chloride Channel Complex Cell Projection Extracellular Exosome	Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Secretory Granule Lumen Phagocytic Vesicle Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Chloride Channel Activity Protein Binding Oxidoreductase Activity	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Female Pregnancy Visual Perception Sensory Perception Of Sound Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	Phagocytosis, Engulfment Actin Filament Organization Central Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Striated Muscle Atrophy Vesicle-mediated Transport Extracellular Matrix Disassembly Cell Projection Organization Cell Projection Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Actin Filament Depolymerization Protein Destabilization Response To Muscle Stretch Positive Regulation Of Apoptotic Process Host-mediated Suppression Of Symbiont Invasion Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Cellular Response To Type II Interferon Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Sensory processing of sound by outer hair cells of the cochlea Amyloid fiber formation
Drugs			Zinc Latrunculin A Copper Zinc acetate
Diseases			Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
GWAS		Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Coronary artery disease in type 1 diabetes ( 32077919) Gout (normal type) ( 32238385) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Mosquito bite size ( 28199695) Periodontal microbiota ( 22699663)	Blood protein levels ( 30072576)
Interacting Genes		8 interacting genes: ACTA1 ACTN1 EZR GSN IQGAP1 LAMTOR5 SRPK1 TPRN	28 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CEBPA CLIC5 CSK ERBB2 FHIT FN1 HSP90AA1 LIMK2 PDE4B PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1 WEE2-AS1
Entrez ID		53405	2934
HPRD ID		06292	00674
Ensembl ID		ENSG00000112782	ENSG00000148180
Uniprot IDs		A0A2R8YGW2 Q49AE1 Q53G01 Q9NZA1	A0A0A0MS51 A0A0A0MT01 A0A384MEF1 A0A8V8TND7 B7Z4U6 P06396
PDB IDs		6Y2H 8Q4I 8Q4J	1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3 7P2B 8VIZ 8VKH
Enriched GO Terms of Interacting Partners?		Actin Filament Actin Filament Organization Actin Cytoskeleton Focal Adhesion Supramolecular Fiber Organization Actin Filament Binding Cortical Actin Cytoskeleton Ruffle Actin Binding Actin Cytoskeleton Organization S100 Protein Binding Establishment Of Epithelial Cell Apical/basal Polarity Actin Filament-based Process Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Polarity Cell-cell Junction Regulation Of Cellular Component Size Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Sarcomere Brush Border Actin Filament Bundle Organization Actin Filament Bundle Assembly Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Microvillus Cytoskeletal Protein Binding Cytosol Cell Development Plasma Membrane Bounded Cell Projection Organization Filopodium Stress Fiber Structural Constituent Of Postsynapse Positive Regulation Of Protein Processing In Phagocytic Vesicle Establishment Of Cell Polarity Terminal Web Assembly Protein Phosphatase Binding Cytoskeleton Organization Muscle Cell Development Cellular Developmental Process Platelet Morphogenesis Cell Projection Organization Protein Localization To Cell Cortex Intestinal D-glucose Absorption Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Stereocilium Maintenance Blood Microparticle	Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Lamellipodium Actin Cytoskeleton Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Locomotion Multicellular Organismal-level Homeostasis Regulation Of Metal Ion Transport Regulation Of Cellular Component Organization Regulation Of Immune System Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Apoptotic Process Nucleotide Binding Regulation Of Monoatomic Ion Transport Regulation Of Cell Migration Regulation Of Programmed Cell Death Focal Adhesion Extracellular Exosome Positive Regulation Of Immune System Process Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Cell Adhesion Regulation Of Cell Motility Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Regulation Of Transport Regulation Of Locomotion Platelet Aggregation Plasma Membrane Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process ATP Binding Regulation Of Calcium Ion Transport Actin Cytoskeleton Organization Signal Transduction Transmembrane Transporter Binding Positive Regulation Of Gene Expression Identical Protein Binding Homotypic Cell-cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoplasm Positive Regulation Of Protein Metabolic Process Cell Motility ERBB Signaling Pathway Cell Body Protein Kinase Binding Positive Regulation Of MAPK Cascade
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