ZNF789 and HEXIM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF789	HEXIM2
Description		zinc finger protein 789	HEXIM P-TEFb complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Serum metabolite levels ( 23093944) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300)	Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		1 interacting genes: HEXIM2	47 interacting genes: ADAMTSL4 AP2M1 CACNB2 CCDC33 CCNT1 CDK9 CFP CTIF DBF4B DRC4 EGFL7 FAM161A GATA1 HEXIM1 HOXA1 HSF2BP IHO1 KPNA3 KPRP KRTAP13-3 LNX1 MEOX2 PICK1 PIM1 PIN1 PRDM14 PSMA1 RNPS1 SAXO1 SDCBP SPRED1 SPRY1 SPRY2 TADA3 TERF1 TERF2 TLE5 TNFAIP1 TRIM14 YPEL3 ZNF250 ZNF426 ZNF500 ZNF558 ZNF655 ZNF699 ZNF789
Entrez ID		285989	124790
HPRD ID		14161	08129
Ensembl ID		ENSG00000198556	ENSG00000168517
Uniprot IDs		Q5FWF6	Q96MH2
PDB IDs
Enriched GO Terms of Interacting Partners?		7SK SnRNA Binding SnRNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition	Negative Regulation Of Lens Fiber Cell Differentiation 7SK SnRNA Binding Regulation Of Lens Fiber Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process P-TEFb Complex SnRNA Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Shelterin Complex Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Telomerase Activity Bud Elongation Involved In Lung Branching Protein Binding Nucleus Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Epithelial To Mesenchymal Transition Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Negative Regulation Of Epithelial To Mesenchymal Transition DNA Binding Regulation Of Cellular Response To Growth Factor Stimulus G-rich Strand Telomeric DNA Binding Negative Regulation Of Epithelial Cell Differentiation Telomeric Loop Disassembly Regulation Of Neurotrophin TRK Receptor Signaling Pathway Telomere Capping Regulation Of Cell Cycle Branch Elongation Of An Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Viral Transcription Protein Serine/threonine Kinase Activator Activity Host-mediated Activation Of Viral Transcription Axis Elongation Regulation Of Receptor Internalization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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