SREK1IP1 and H2BC15

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SREK1IP1	H2BC15
Name		SREK1 interacting protein 1	H2B clustered histone 15
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	MRNA Processing RNA Splicing	Nucleosome Assembly
Pathways		None	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
GWAS		General cognitive ability ( 29844566 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: DAXX
Interacting Genes		29 interacting genes: AGPAT3 CCNL1 CT45A1 DDIT4L ELOA2 FGF10 GTF2H4 H2BC15 HPRT1 HSD17B14 LYAR MACROH2A1 NKAPD1 NKAPL NME1 PPCDC PRPF40A PRR13 RBM39 RNF151 RP9 RP9P RPL9 SDCBP SDCBP2 SPMIP2 STAC3 THAP1 UBC	19 interacting genes: BCCIP CEBPA EWSR1 FAM133A FAM9A H1-7 H2AB2 H2AB3 H2AC19 H2AC4 H2AC8 MACROH2A1 MACROH2A2 NKAPD1 PRR13 RPL22 SPANXN2 SREK1IP1 TSPYL2
Entrez ID		285672	8341
HPRD ID		08210	11899
Ensembl ID		ENSG00000153006	ENSG00000233822
Uniprot IDs		Q8N9Q2	Q99877
PDB IDs		Not available	8OL1
GO Terms Enriched among Interactors		None	Structural Constituent Of Chromatin Nucleosome Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Protein Heterodimerization Activity Nucleosome Assembly Nucleosome Organization Chromatin Organization Epigenetic Regulation Of Gene Expression Chromatin Remodeling Chromosome Protein-DNA Complex Assembly Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Gene Expression RDNA Binding Barr Body Negative Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Metabolic Process Nucleus Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Chromatin DNA Binding CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Positive Regulation Of Keratinocyte Differentiation DNA Binding Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Biosynthetic Process Nucleolus Positive Regulation Of Epidermis Development Protein Localization To Chromosome, Centromeric Region Nucleosomal DNA Binding Regulation Of Keratinocyte Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Translation At Presynapse Negative Regulation Of Protein Localization To Chromosome, Telomeric Region Regulation Of Transcription By RNA Polymerase I Protein Localization To Chromatin Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide ADP-D-ribose Binding Regulation Of NAD Metabolic Process Regulation Of Epidermal Cell Differentiation