H2BC15 and H2AB3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		H2BC15	H2AB3
Name		H2B clustered histone 15	H2A.B variant histone 3
Structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome	Nucleosome Euchromatin Nucleus Chromosome
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly	Nucleosome Assembly MRNA Processing Heterochromatin Formation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: DAXX	None recorded
Interacting Genes		19 interacting genes: BCCIP CEBPA EWSR1 FAM133A FAM9A H1-7 H2AB2 H2AB3 H2AC19 H2AC4 H2AC8 MACROH2A1 MACROH2A2 NKAPD1 PRR13 RPL22 SPANXN2 SREK1IP1 TSPYL2	3 interacting genes: H2BC13 H2BC15 MESD
Entrez ID		8341	83740
HPRD ID		11899	06581
Ensembl ID		ENSG00000233822	ENSG00000277745
Uniprot IDs		Q99877	P0C5Z0
PDB IDs		8OL1	6A7U 6M4G 6M4H
GO Terms Enriched among Interactors		Structural Constituent Of Chromatin Nucleosome Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Protein Heterodimerization Activity Nucleosome Assembly Nucleosome Organization Chromatin Organization Epigenetic Regulation Of Gene Expression Chromatin Remodeling Chromosome Protein-DNA Complex Assembly Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Gene Expression RDNA Binding Barr Body Negative Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Metabolic Process Nucleus Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Chromatin DNA Binding CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Positive Regulation Of Keratinocyte Differentiation DNA Binding Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Biosynthetic Process Nucleolus Positive Regulation Of Epidermis Development Protein Localization To Chromosome, Centromeric Region Nucleosomal DNA Binding Regulation Of Keratinocyte Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Translation At Presynapse Negative Regulation Of Protein Localization To Chromosome, Telomeric Region Regulation Of Transcription By RNA Polymerase I Protein Localization To Chromatin Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide ADP-D-ribose Binding Regulation Of NAD Metabolic Process Regulation Of Epidermal Cell Differentiation	Nucleosome Nucleosome Assembly Nucleosome Organization Structural Constituent Of Chromatin Protein-DNA Complex Assembly Protein Heterodimerization Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Chromatin Remodeling Chromosome Low-density Lipoprotein Particle Receptor Binding Protein Localization To Cell Surface Chromatin Organization Mesoderm Development Protein Folding Chaperone