SREK1IP1 and FGF10

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SREK1IP1	FGF10
Name		SREK1 interacting protein 1	fibroblast growth factor 10
Structure		No pdb structure
GO Annotations	Cellular Component	None	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	MRNA Processing RNA Splicing	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Angiogenesis Metanephros Development Organ Induction Mesonephros Development Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Blood Vessel Remodeling Metanephros Morphogenesis Chemotaxis Cell-cell Signaling Determination Of Left/right Symmetry Salivary Gland Development Salivary Gland Morphogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Smoothened Signaling Pathway Embryonic Pattern Specification Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Keratinocyte Proliferation Wnt Signaling Pathway Pituitary Gland Development Neurogenesis Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Lung Development Regulation Of Cell Migration Embryonic Genitalia Morphogenesis Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Thyroid Gland Development Otic Vesicle Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Hair Follicle Morphogenesis Embryonic Camera-type Eye Development Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of ATP-dependent Activity Lacrimal Gland Development Regulation Of Activin Receptor Signaling Pathway Protein Localization To Cell Surface Somatic Stem Cell Population Maintenance Limb Morphogenesis Organ Growth Wound Healing Tissue Regeneration Inner Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Muscle Cell Fate Commitment Positive Regulation Of MAPK Cascade Keratinocyte Proliferation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Regulation Of Saliva Secretion Vascular Endothelial Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Blood Vessel Morphogenesis Spleen Development Thymus Development Embryonic Digestive Tract Morphogenesis Digestive Tract Development Embryonic Digestive Tract Development Animal Organ Formation Epidermis Morphogenesis Semicircular Canal Morphogenesis Branching Morphogenesis Of An Epithelial Tube Female Genitalia Morphogenesis Male Genitalia Morphogenesis Positive Regulation Of Lymphocyte Proliferation Epithelial Cell Proliferation Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation White Fat Cell Differentiation Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Keratinocyte Migration Radial Glial Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Limb Development Limb Bud Formation Lung Morphogenesis Lung Epithelium Development Lung Saccule Development Bronchiole Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Bud Elongation Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Lung Development Type II Pneumocyte Differentiation Prostatic Bud Formation Respiratory System Development Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Submandibular Salivary Gland Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Branch Elongation Involved In Salivary Gland Morphogenesis Semicircular Canal Fusion Mesenchymal Cell Differentiation Involved In Lung Development Secretion By Lung Epithelial Cell Involved In Lung Growth Lung Proximal/distal Axis Specification Tear Secretion White Fat Cell Proliferation Positive Regulation Of White Fat Cell Proliferation ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Harderian Gland Development Positive Regulation Of Hair Follicle Cell Proliferation Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		None	PI3K Cascade PIP3 activates AKT signaling FGFR1b ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Regulation of gene expression in early pancreatic precursor cells Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells Developmental Lineage of Mammary Stem Cells
Diseases		None	Aplasia of lacrimal and salivary glands Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
GWAS		General cognitive ability ( 29844566 )	Alzheimer disease and age of onset ( 26830138 ) Basal cell carcinoma ( 31174203 ) Breast cancer ( 29059683 31757997 ) Dentures ( 31235808 ) Estimated glomerular filtration rate ( 31152163 ) FEV1 ( 30804560 ) High altitude adaptation ( 28373541 ) Keratinocyte cancer (MTAG) ( 31174203 ) Lung function (FVC) ( 30175238 30804560 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Parkinson's disease ( 26227905 ) Prostate cancer ( 21743467 ) Refractive error ( 32231278 )
Interacting Genes		29 interacting genes: AGPAT3 CCNL1 CT45A1 DDIT4L ELOA2 FGF10 GTF2H4 H2BC15 HPRT1 HSD17B14 LYAR MACROH2A1 NKAPD1 NKAPL NME1 PPCDC PRPF40A PRR13 RBM39 RNF151 RP9 RP9P RPL9 SDCBP SDCBP2 SPMIP2 STAC3 THAP1 UBC	6 interacting genes: FBXO7 FGFR1 FGFR2 POMC SREK1IP1 THAP1
Entrez ID		285672	2255
HPRD ID		08210	03665
Ensembl ID		ENSG00000153006	ENSG00000070193
Uniprot IDs		Q8N9Q2	O15520
PDB IDs		Not available	1NUN
GO Terms Enriched among Interactors		None	Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Lipase Activity Lung-associated Mesenchyme Development Branching Involved In Salivary Gland Morphogenesis Fibroblast Growth Factor Binding Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Morphogenesis Of A Branching Structure Mesenchyme Development Inner Ear Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of Heart Growth Kidney Epithelium Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Positive Regulation Of Oxytocin Production Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Epithelial To Mesenchymal Transition Biomineral Tissue Development Regulation Of Organ Growth Regulation Of Mitotic Cell Cycle Lung Development Stem Cell Differentiation