RSPO1 and RNF43

Number of citations of the paper that reports this interaction (PMID 23756651)
10

Data Source:
BioGRID (pull down)

		RSPO1	RNF43
Gene Name		R-spondin 1	ring finger protein 43
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus	Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Heparin Binding	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Male Meiosis Regulation Of Gene Expression Positive Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Male Germ Cell Proliferation	Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Stem Cell Proliferation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS			Circulating myeloperoxidase levels (plasma) ( 23620142) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		2 interactors: RNF43 ZNRF3	8 interactors: RSPO1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N
Entrez ID		284654	54894
HPRD ID		08288	07896
Ensembl ID		ENSG00000169218	ENSG00000108375
Uniprot IDs		Q2MKA7	Q68DV7
PDB IDs		4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4KNG 4KT1 4LI2	4KNG
Enriched GO Terms of Interacting Partners?		Wnt Receptor Catabolic Process Receptor Catabolic Process Receptor Metabolic Process Stem Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cell Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Non-canonical Wnt Signaling Pathway Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Catabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Organ Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Innate Immune Response Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Protein Modification Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Cellular Protein Metabolic Process Proteolysis Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Spindle Checkpoint Innate Immune Response Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Response To Hypoxia Regulation Of Immune Response
Tagcloud ?			adherens anoikis arid1a cdh1 clustered complexity ctnna2 driver escape gli3 guided highlights hotspots illustrate integrative junction landscape muc6 multidimensional mutational organoid personalized perturbations perturbed players rhoa road signatures top
Tagcloud (Difference) ?			adherens anoikis arid1a cdh1 clustered complexity ctnna2 driver escape gli3 guided highlights hotspots illustrate integrative junction landscape muc6 multidimensional mutational organoid personalized perturbations perturbed players rhoa road signatures top
Tagcloud (Intersection) ?