TPRX1 and ZNRF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPRX1	ZNRF4
Description		tetrapeptide repeat homeobox 1	zinc and ring finger 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Organelle Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Maternal-to-zygotic Transition Of Gene Expression	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Defense Response To Bacterium Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Intracellular Signal Transduction
Pathways		Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS
Interacting Genes		18 interacting genes: ATXN1 FANCG GOLGA2 GOLGA6L9 INCA1 KRTAP19-7 KRTAP6-2 MKRN3 NELFB OIP5 PRR20A PRR20B PRR20C PRR20D PRR20E SERTAD3 USHBP1 ZNRF4	13 interacting genes: NT5E RIPK2 TPRX1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2G2 UBE2N UBE2W UPK2
Entrez ID		284355	148066
HPRD ID		13447	15895
Ensembl ID		ENSG00000178928	ENSG00000105428
Uniprot IDs		A0A8V8TMK4 D2CFI5 Q8N7U7	Q8WWF5
PDB IDs
Enriched GO Terms of Interacting Partners?			Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Nucleotide Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein K11-linked Ubiquitination Transferase Activity Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Proteolysis Regulation Of Protein Polyubiquitination Protein Metabolic Process TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination TOR Signaling Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of TORC1 Signaling Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of TOR Signaling Regulation Of Protein Ubiquitination Nucleoplasm Regulation Of Post-translational Protein Modification Adenosine Biosynthetic Process Cellular Response To Nutrient Levels Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Maternal-to-zygotic Transition Of Gene Expression Antiviral Innate Immune Response DNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex
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