TMEM102 and SLC12A4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM102	SLC12A4
Description		transmembrane protein 102	solute carrier family 12 member 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Cell Surface Membrane Protein-containing Complex	Lysosomal Membrane Plasma Membrane Membrane Synapse
	Molecular Function	Protein Binding	Protein Binding ATP Binding Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Protein Serine/threonine Kinase Binding
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of T Cell Chemotaxis Response To Cytokine Positive Regulation Of Cell Adhesion Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of T Cell Migration	Monoatomic Ion Transport Potassium Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Potassium Ion Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Cation-coupled Chloride cotransporters
Drugs			Potassium chloride Bumetanide
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		2 interacting genes: SLC12A4 YWHAG	10 interacting genes: AP3M1 ATF7IP CNFN CYSRT1 KRTAP12-2 KRTAP19-2 MB21D2 MTNR1B TMEM102 ZNF655
Entrez ID		284114	6560
HPRD ID		08215	04987
Ensembl ID		ENSG00000181284	ENSG00000124067
Uniprot IDs		Q8N9M5	B4DF30 Q9UP95
PDB IDs			6KKR 6KKT 6KKU 7AIP 7AIQ 7AIR 7TTH 7TTI
Enriched GO Terms of Interacting Partners?		Chloride Ion Homeostasis Potassium:chloride Symporter Activity Chloride:monoatomic Cation Symporter Activity Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Kinase C Inhibitor Activity Insulin-like Growth Factor Receptor Binding Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding
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