FAM98B and PLCB2

		FAM98B	PLCB2
Description		family with sequence similarity 98 member B	phospholipase C beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm TRNA-splicing Ligase Complex	Cytoplasm Cytosol G-protein Beta/gamma-subunit Complex Neuronal Dense Core Vesicle
	Molecular Function	RNA Binding Protein Binding Protein Methyltransferase Activity Identical Protein Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phospholipid Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding Phosphatidylinositol Phospholipase C Activity
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Protein Methylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste Release Of Sequestered Calcium Ion Into Cytosol
Pathways		tRNA processing in the nucleus	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs
Diseases
GWAS		Psychosis (atypical) ( 24132900) Systemic lupus erythematosus ( 24871463)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)
Interacting Genes		21 interacting genes: CEBPA MIR106A MIR10B MIR138-1 MIR141 MIR16-1 MIR18B MIR199A2 MIR200B MIR200C MIR205 MIR222 MIR34A MIR7-3 MIR9-1 MIRLET7A1 MIRLET7A2 MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G	7 interacting genes: GNAQ MAP2K3 MAP2K6 NHERF1 SNCA TRPC3 TRPM7
Entrez ID		283742	5330
HPRD ID		08786	04985
Ensembl ID		ENSG00000171262	ENSG00000137841
Uniprot IDs		Q52LJ0	Q00722 Q59F77 Q9BVT6
PDB IDs			2FJU 2ZKM
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Translation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Metabolic Process Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Destabilization RNA Destabilization Regulation Of Endothelial Cell Migration Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Developmental Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Osteoblast Differentiation Negative Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Response To Testosterone Regulation Of Phosphorus Metabolic Process NLRP1 Inflammasome Complex Assembly Response To Ketone Regulation Of Protein Kinase Activity Cellular Response To UV-B Regulation Of Phosphorylation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Calcium Channel Activity Response To Lipid MAP Kinase Kinase Activity Regulation Of Kinase Activity Response To Magnesium Ion Response To Light Stimulus Detection Of Abiotic Stimulus Response To UV-B Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Kinase Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Protein Serine Kinase Activity Regulation Of MAPK Cascade Extracellular Matrix Binding GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Regulation Of Cell Communication Response To Radiation Regulation Of Signaling Phototransduction Cellular Response To Stress S-methyl-5-thioadenosine Phosphorylase Activity Negative Regulation Of Centriole-centriole Cohesion Protein Serine/threonine Kinase Activity Cardiac Muscle Contraction Regulation Of Protein Phosphorylation Canonical Inflammasome Complex Assembly Pyroptotic Inflammatory Response Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Protein Kinase Inhibitor Activity Inorganic Ion Homeostasis Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Fibroblast Migration Calcium Ion Transmembrane Transport Renal Phosphate Ion Absorption Protein-containing Complex Assembly
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