GLRA2 and POLA1

		GLRA2	POLA1
Description		glycine receptor alpha 2	DNA polymerase alpha 1, catalytic subunit
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GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Cell Projection Synapse Postsynaptic Membrane Glycinergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Cytosol Nuclear Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Glycine-gated Chloride Ion Channel Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Protein Kinase Binding DNA Polymerase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Neuropeptide Signaling Pathway Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Chloride Transmembrane Transport	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair
Pathways		Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis
Drugs		Glycine Lindane Picrotoxin Ethanol Memantine Taurine	Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS			Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		5 interacting genes: BAG6 DDX24 GDI2 PSD SEC23A	18 interacting genes: CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5
Entrez ID		2742	5422
HPRD ID		02379	02416
Ensembl ID		ENSG00000101958	ENSG00000101868
Uniprot IDs		P23416	A6NMQ1 P09884
PDB IDs		5BKF 5BKG 7KUY 7L31	1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7 7N2M 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V 9MJ5
Enriched GO Terms of Interacting Partners?		Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Localization To Cilium Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex Alpha DNA Polymerase:primase Complex COPII-coated Vesicle Budding DNA Replication, Synthesis Of Primer	DNA Metabolic Process DNA Replication DNA Repair Nucleic Acid Metabolic Process DNA-templated DNA Replication DNA Damage Response Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromosome Organization DNA Replication, Synthesis Of Primer Macromolecule Metabolic Process Chromosome, Telomeric Region Chromatin Binding Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleoplasm Double-strand Break Repair Regulation Of Chromosome Organization Response To Gamma Radiation Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process Recombinational Repair Chromosome Cellular Response To Radiation DNA Binding G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Activity DNA Replication Proofreading DNA Biosynthetic Process DNA Replication Initiation Cellular Response To Gamma Radiation Site Of Double-strand Break Telomere Maintenance Nucleus Negative Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome PML Body DNA Recombination Alpha DNA Polymerase:primase Complex Glial Cell Apoptotic Process Response To Radiation Regulation Of Cell Cycle Phase Transition Telomere Organization Histone Kinase Activity Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Cell Cycle Process 4 Iron, 4 Sulfur Cluster Binding Double-strand Break Repair Via Homologous Recombination
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