GLG1 and NFKB2

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vitro)

		GLG1	NFKB2
Gene Name		golgi glycoprotein 1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Extracellular Matrix Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex
	Molecular Function	Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Blood Coagulation Negative Regulation Of Protein Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Leukocyte Migration Bone Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway Follicular Dendritic Cell Differentiation Germinal Center Formation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Cell surface interactions at the vascular wall	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by Interleukins Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 processing TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Breast cancer ( 18463975) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		2 interactors: NFKB2 SELE	35 interactors: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		2734	4791
HPRD ID		02855	01239
Ensembl ID			ENSG00000077150
Uniprot IDs		Q92896	Q00653
PDB IDs			1A3Q 2D96 3DO7
Enriched GO Terms of Interacting Partners?		Follicular Dendritic Cell Differentiation Inflammatory Response Response To Cytokine Germinal Center Formation Leukocyte Tethering Or Rolling Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Immune System Process Positive Regulation Of Receptor Internalization Cellular Extravasation Regulation Of Receptor Internalization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Immune System Process Positive Regulation Of Receptor-mediated Endocytosis Defense Response NIK/NF-kappaB Signaling Spleen Development Activation Of Phospholipase C Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Phospholipase C Activity I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Phospholipase Activity Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Response To Interleukin-1 Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Leukocyte Migration Calcium-mediated Signaling Immune System Process Positive Regulation Of Endocytosis Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Second-messenger-mediated Signaling Positive Regulation Of Cellular Metabolic Process	I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Gene Expression Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Transcription, DNA-templated TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Pattern Recognition Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Macromolecule Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression Intracellular Signal Transduction
Tagcloud ?		apoe apolipoprotein atherosclerosis atherosclerotic backcrossing c57bl6 carrying cgr deficiency e10 embryonic esl fewer fibroblast generations glycoprotein golgi heterozygous homocysteine intercrossed latent lethality ltcp multifunctional plaque selectin transforming viable widespread	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Difference) ?		apoe apolipoprotein atherosclerosis atherosclerotic backcrossing c57bl6 carrying cgr deficiency e10 embryonic esl fewer fibroblast generations glycoprotein golgi heterozygous homocysteine intercrossed latent lethality ltcp multifunctional plaque selectin transforming viable widespread	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Intersection) ?