GCLC and GCLM

Number of citations of the paper that reports this interaction (PMID 9841880)
13

Data Source:
BioGRID (biochemical, pull down)

		GCLC	GCLM
Gene Name		glutamate-cysteine ligase, catalytic subunit	glutamate-cysteine ligase, modifier subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Magnesium Ion Binding Glutamate-cysteine Ligase Activity ATP Binding Glutamate Binding ADP Binding Protein Heterodimerization Activity Coenzyme Binding	Glutamate-cysteine Ligase Activity Enzyme Regulator Activity Glutamate-cysteine Ligase Catalytic Subunit Binding Protein Heterodimerization Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Xenobiotic Metabolic Process Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Heat Response To Hormone L-ascorbic Acid Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Response To Arsenic-containing Substance Regulation Of Blood Vessel Size Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Sulfur Amino Acid Metabolic Process Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Xenobiotic Metabolic Process Response To Oxidative Stress Apoptotic Mitochondrial Changes Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Glutamate-cysteine Ligase Activity Response To Drug Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Regulation Of Blood Vessel Size Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Glutathione conjugation Metabolism of amino acids and derivatives Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Glutathione synthesis and recycling Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		L-Glutamic Acid L-Cysteine	L-Glutamic Acid L-Cysteine
Diseases
GWAS			Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		2 interactors: CCL22 GCLM	4 interactors: CALM1 GCLC IRF7 STOX1
Entrez ID		2729	2730
HPRD ID		06032	03106
Ensembl ID		ENSG00000001084
Uniprot IDs		E1CEI4 P48506 Q14TF0	M5A959 P48507
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glutamate-cysteine Ligase Activity Response To Nitrosative Stress Cysteine Metabolic Process Regulation Of Mitochondrial Depolarization Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Peptide Biosynthetic Process Regulation Of Membrane Depolarization Sulfur Amino Acid Metabolic Process Serine Family Amino Acid Metabolic Process Glutathione Metabolic Process Apoptotic Mitochondrial Changes Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Ligase Activity Dicarboxylic Acid Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Peptide Metabolic Process Regulation Of Ion Homeostasis Cell Chemotaxis Negative Regulation Of Neuron Apoptotic Process	Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Ion Homeostasis MDA-5 Signaling Pathway Monosaccharide Metabolic Process Interferon-beta Production Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Response To Nitrosative Stress Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Negative Regulation Of Cellular Metabolic Process Mitochondrion Organization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Metabolic Process Establishment Of Viral Latency Immune Response-regulating Signaling Pathway Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Type I Interferon Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Detection Of Calcium Ion L-ascorbic Acid Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Regulation Of Monocyte Differentiation Type I Interferon Production Regulation Of Macrophage Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Cellular Response To Virus Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Mitochondrial Depolarization Negative Regulation Of Peptidyl-threonine Phosphorylation Glutathione Biosynthetic Process Regulation Of Signaling Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Positive Regulation Of Interferon-alpha Production Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity
Tagcloud ?		acetaminophen acetylcysteine antidote apap assessments augmenter constituents exerted exerts gclm hepatotoxicity histologic ho injured livers morphologic nac nqo1 poisoning possessed postdosing proliferating regenerative rescue schisandra sphenanthera tablet wuzhi wz	acetaminophen acetylcysteine antidote apap assessments augmenter constituents exerted exerts gclc hepatotoxicity histologic ho injured livers morphologic nac nqo1 poisoning possessed postdosing proliferating regenerative rescue schisandra sphenanthera tablet wuzhi wz
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		acetaminophen acetylcysteine antidote apap assessments augmenter constituents exerted exerts gclc gclm hepatotoxicity histologic ho injured livers morphologic nac nqo1 poisoning possessed postdosing proliferating regenerative rescue schisandra sphenanthera tablet wuzhi wz