TINAG and TMEM45B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TINAG	TMEM45B
Description		tubulointerstitial nephritis antigen	transmembrane protein 45B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Lysosome	Lysosome Lysosomal Membrane Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane
	Molecular Function	Nucleotide Binding Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity	Protein Binding
	Biological Process	Proteolysis Cell Adhesion	Immune System Process Innate Immune Response Response To Pain
Pathways
Drugs
Diseases
GWAS		Morning person ( 30696823) QRS interval (sulfonylurea treatment interaction) ( 27958378) Radiation response ( 20923822)	Breast cancer ( 22383897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Serum metabolite levels ( 33031748) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Type 2 diabetes ( 22238593)
Interacting Genes		3 interacting genes: CPB2 TERF1 TMEM45B	41 interacting genes: ANKRD46 APOD APOL2 AQP1 ARLN BMP10 C3orf52 CACNG1 CDS2 CYB561D2 DOLK FAM3C FKBP8 GIMAP1 INSIG2 LAT NSG1 PLN PLP1 PLPP4 SEC22A SEC23A SMAGP SMIM1 SNORC SYNGR1 TINAG TMEM128 TMEM218 TMEM229B TMEM243 TMEM254 TMEM60 TMEM97 TNFRSF10C TREX1 TSPAN33 UBE2G2 UPK1B VAMP5 VKORC1
Entrez ID		27283	120224
HPRD ID		09483	14020
Ensembl ID		ENSG00000137251	ENSG00000151715
Uniprot IDs		Q6NSC1 Q9UJW2	Q96B21
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping DNA Binding, Bending Response To Pain Fibrinolysis Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Metallocarboxypeptidase Activity Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Carboxypeptidase Activity Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Involved In Meiotic Cell Cycle Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Positive Regulation Of Telomere Maintenance Multicellular Organismal Response To Stress Negative Regulation Of Chromosome Organization Chromosome Localization	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane
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