BTN2A2 and SLC1A3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BTN2A2	SLC1A3
Description		butyrophilin subfamily 2 member A2	solute carrier family 1 member 3
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Cell Periphery Membrane Protein Complex
	Molecular Function	Signaling Receptor Binding Protein Binding	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Acidic Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Amino Acid Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cytokine Production Negative Regulation Of Cytokine Production Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Activated T Cell Proliferation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Neurotransmitter Uptake Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Sodium Ion Homeostasis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Light Stimulus Gamma-aminobutyric Acid Biosynthetic Process Response To Wounding Neutral Amino Acid Transport L-glutamate Transmembrane Transport Cranial Nerve Development Auditory Behavior Response To Antibiotic Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance L-glutamate Import Transepithelial Transport D-aspartate Import Across Plasma Membrane Cellular Response To Cocaine Potassium Ion Transmembrane Transport Import Into Cell L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways		Butyrophilin (BTN) family interactions	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC-mediated transport of amino acids
Drugs			Glutamic acid
Diseases			Episodic ataxias
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) General cognitive ability ( 29844566) Headache ( 29397368) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver iron content ( 34128465) Neurociticism ( 29500382) Refractive error ( 32231278) Schizophrenia ( 19571809) Smoking initiation ( 33082346) Subcortical volume (MOSTest) ( 32665545)	Depression in smokers ( 30219690) Heel bone mineral density ( 28869591 30598549) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Malaria ( 31844061) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		46 interacting genes: AQP6 ARL13B BIK CD53 CD79A CISD2 CREB3 EBP ELOVL4 EMP1 ERGIC3 EVI2B FAM209A FATE1 FFAR2 GJB3 GPR42 GPRC5D GPX8 HSD3B7 KIR2DL3 LHFPL5 LMNA MRM3 MUC1 PEX12 PSMA3 SEC11C SLC10A1 SLC10A6 SLC14A1 SLC16A2 SLC18A1 SLC1A3 SLC30A4 SLC35H1 SLC39A2 SPNS3 STX1A SYT1 TMEM14B TMEM179B TMEM237 TMEM31 TMEM52B TMX2	6 interacting genes: BTN2A2 MGST3 SGK1 TMEM120B TMEM128 ZDHHC17
Entrez ID		10385	6507
HPRD ID		12545	02523
Ensembl ID		ENSG00000124508	ENSG00000079215
Uniprot IDs		Q8WVV5	A0A087WT87 A0A087X0U3 B4DF14 P43003 Q7Z5T0 Q8N169
PDB IDs		8IH4	5LLM 5LLU 5LM4 5MJU 7NPW
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Protein Binding Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Neurotransmitter Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?