TPK1 and OPLAH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPK1	OPLAH
Description		thiamin pyrophosphokinase 1	5-oxoprolinase, ATP-hydrolysing
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Thiamine Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Thiamine Binding Identical Protein Binding UTP Thiamine Diphosphokinase Activity	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Hydrolase Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding
	Biological Process	Thiamine Metabolic Process Thiamine Diphosphate Biosynthetic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA	Glutathione Metabolic Process
Pathways		Vitamin B1 (thiamin) metabolism	Glutathione synthesis and recycling Defective OPLAH causes OPLAHD
Drugs		Thiamine Pyrithiamine Pyrophosphate	Glutamic acid
Diseases
GWAS		Fruit consumption ( 32066663) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Iris color (b* coordinate) ( 30895295) Smoking status (heavy vs never) ( 26423011)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		1 interacting genes: OPLAH	6 interacting genes: GK HOXA1 POU6F2 TPK1 UBC ZNF451
Entrez ID		27010	26873
HPRD ID		06967	14880
Ensembl ID		ENSG00000196511	ENSG00000178814
Uniprot IDs		A0A090N8Y0 B3KRJ6 F5GZG6 Q6ZQX6 Q9H3S4	O14841
PDB IDs		3S4Y 9HJC
Enriched GO Terms of Interacting Partners?		5-oxoprolinase (ATP-hydrolyzing) Activity Glutathione Metabolic Process	Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Semicircular Canal Formation UTP Thiamine Diphosphokinase Activity Thiamine Binding Thiamine Diphosphokinase Activity Abducens Nerve Formation Optokinetic Behavior Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Metabolic Process Mitochondrial Outer Membrane Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Initiation Thiamine-containing Compound Metabolic Process Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Alcohol Metabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Ligase Activity Glycerol Metabolic Process Protein Tag Activity Triglyceride Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?