AMHR2 and AMH

Number of citations: 0 (PubMedID 8889695)
Data Source: HPRD (in vitro)

		AMHR2	AMH
Name		anti-Mullerian hormone receptor type 2	anti-Mullerian hormone
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Kinase Activity Transferase Activity Hormone Binding Protein Homodimerization Activity Metal Ion Binding Anti-Mullerian Hormone Receptor Activity	Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity
	Biological Process	Mullerian Duct Regression Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Sex Differentiation Male Gonad Development Female Gonad Development BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Anti-Mullerian Hormone Receptor Signaling Pathway	Ovarian Follicle Development Preantral Ovarian Follicle Growth Urogenital System Development Mullerian Duct Regression Cell-cell Signaling Gonadal Mesoderm Development Sex Determination Sex Differentiation Gonad Development Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Cell Differentiation Leydig Cell Differentiation Development Of Primary Male Sexual Characteristics Positive Regulation Of SMAD Protein Signal Transduction Anti-Mullerian Hormone Receptor Signaling Pathway Negative Regulation Of Ovarian Follicle Development
Pathways		Signaling by BMP	Signaling by BMP Transcriptional regulation of testis differentiation
Drugs		ATP	None
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism	46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS		No GWAS studies recorded	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Pulse pressure ( 26390057 27618447 30487518 )
Novel Interactors		2 novel interactors: TUBA1A TUBA1C	1 novel interactors: TLE5
Interacting Genes		4 interacting genes: AMH BMPR1B MAL TGFBR1	6 interacting genes: AMHR2 ARL8B EGFR ETV5 PCSK5 ZMAT2
Entrez ID		269	268
HPRD ID		02978	02979
Ensembl ID		ENSG00000135409	ENSG00000104899
Uniprot IDs		Q16671	P03971
PDB IDs		7L0J	7L0J
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Ovulation Cycle Process Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors SMAD Binding Regulation Of Chondrocyte Differentiation Mesenchyme Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cytoplasmic Microtubule Regulation Of Apoptotic Signaling Pathway Regulation Of SMAD Protein Signal Transduction Cell Differentiation Regulation Of Cartilage Development Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Reproductive Process Negative Regulation Of Ovarian Follicle Development Cellular Developmental Process Preantral Ovarian Follicle Growth Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Cilium Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Structural Constituent Of Cytoskeleton Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Gonad Development Central Nervous System Neuron Differentiation Membrane Raft Polarization Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Mitotic Cell Cycle Mullerian Duct Regression Nucleotide Binding Ovarian Cumulus Expansion Protein Localization To Paranode Region Of Axon Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Anti-Mullerian Hormone Receptor Signaling Pathway	Mullerian Duct Regression Anti-Mullerian Hormone Receptor Signaling Pathway Anti-Mullerian Hormone Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Embryonic Organ Development Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Biological Process Involved In Interaction With Host Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Male Germ-line Stem Cell Asymmetric Division Viral Life Cycle Cytokine Precursor Processing Renin Secretion Into Blood Stream Viral Process Calcium Ion Regulated Lysosome Exocytosis Cytolytic Granule Membrane Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Endosome To Lysosome Transport Of Low-density Lipoprotein Particle Protein Localization To Early Endosome Viral Exocytosis Skeletal System Development