WFIKKN2 and MSTN

Number of citations of the paper that reports this interaction (PMID 12595574)
30

Data Source:
HPRD (in vitro)

		WFIKKN2	MSTN
Gene Name		WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	myostatin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Space Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Metalloendopeptidase Inhibitor Activity	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding
	Biological Process	Skeletal System Development Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Binding Negative Regulation Of DNA Binding Muscle Fiber Development Palate Development	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of MAPK Cascade Response To Estrogen Response To Ethanol Positive Regulation Of Transcription, DNA-templated Cell Development Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: MSTN	6 interactors: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2
Entrez ID		124857	2660
HPRD ID		18303	03474
Ensembl ID		ENSG00000173714	ENSG00000138379
Uniprot IDs		C9J6G4 Q8TEU8	O14793 Q53S46
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Myoblast Proliferation Negative Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Skeletal Muscle Cell Differentiation Skeletal Muscle Atrophy Striated Muscle Atrophy Regulation Of Myoblast Proliferation Muscle Atrophy Regulation Of Satellite Cell Proliferation Skeletal Muscle Adaptation Negative Regulation Of Muscle Hypertrophy Response To Muscle Activity Response To Gravity Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Development Skeletal Muscle Tissue Regeneration Cellular Response To Dexamethasone Stimulus Negative Regulation Of Stem Cell Differentiation Response To Dexamethasone Response To Testosterone Response To Electrical Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Muscle Organ Development Tissue Regeneration Cellular Response To Glucocorticoid Stimulus Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Corticosteroid Stimulus Response To Activity SMAD Protein Signal Transduction Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Developmental Growth Ovulation Cycle Process Response To Heat Ovulation Cycle Regulation Of Striated Muscle Tissue Development Response To Ethanol Transforming Growth Factor Beta Receptor Signaling Pathway Response To Glucocorticoid Response To Corticosteroid Cellular Response To Steroid Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Temperature Stimulus Response To Transforming Growth Factor Beta Response To Estrogen Negative Regulation Of Growth Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Muscle System Process Muscle Organ Development	Regulation Of Activin Receptor Signaling Pathway Muscle Fiber Development Palate Development Cell Differentiation Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Striated Muscle Cell Development Sarcomerogenesis Collateral Sprouting In Absence Of Injury Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development System Development Collateral Sprouting Axon Midline Choice Point Recognition Myosin Filament Assembly Striated Muscle Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Lung Development Anterior/posterior Pattern Specification Respiratory Tube Development Regulation Of Binding Negative Regulation Of Endopeptidase Activity Positive Regulation Of Activin Receptor Signaling Pathway Anatomical Structure Development Negative Regulation Of Peptidase Activity Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Lymphatic Endothelial Cell Differentiation Respiratory System Development Neuron Remodeling Negative Regulation Of Activin Receptor Signaling Pathway Kidney Development Muscle Cell Differentiation Otic Vesicle Formation Renal System Development Lymphangiogenesis Organ Development Negative Regulation Of Proteolysis Otic Vesicle Morphogenesis Developmental Process Lymph Vessel Morphogenesis Negative Regulation Of Protein Processing Urogenital System Development Regulation Of Endopeptidase Activity
Tagcloud ?			adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting
Tagcloud (Difference) ?			adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting
Tagcloud (Intersection) ?