CNNM1 and PTP4A2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CNNM1	PTP4A2
Description		cyclin and CBS domain divalent metal cation transport mediator 1	protein tyrosine phosphatase 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Neuronal Cell Body	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity
	Biological Process	Monoatomic Ion Transport Magnesium Ion Homeostasis Transmembrane Transport
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010 33339817) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 22412388) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954)	Appendicular lean mass ( 33097823) Body mass index ( 26426971)
Interacting Genes		3 interacting genes: HSF2BP PTP4A1 PTP4A2	13 interacting genes: AKAP8L ATF7 CARS1 CNNM1 CNNM3 DHX15 DUSP22 EWSR1 HSP90AA1 HSP90AB1 MPO RABGGTB WIPF2
Entrez ID		26507	8073
HPRD ID		07417	03348
Ensembl ID		ENSG00000119946	ENSG00000184007
Uniprot IDs		A0A8Q3SIV9 B4DKF7 B7Z5S3 Q9NRU3	Q12974
PDB IDs			5K22 5K23 5K25 6WUR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chromatin Organization Y Chromosome Endosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity X Chromosome Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Protection From Non-homologous End Joining At Telomere Female Meiosis I Regulation Of Heterochromatin Formation Early Endosome Double-strand Break Repair Involved In Meiotic Recombination DNA-templated Transcription Telomere Maintenance In Response To DNA Damage Mitotic G1/S Transition Checkpoint Signaling Cellular Response To Nitric Oxide Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of DNA-templated DNA Replication Cellular Response To Reactive Nitrogen Species Centrosome Duplication Female Meiotic Nuclear Division Response To Nitric Oxide DNA Repair Centriole Replication Regulation Of Chromatin Organization Male Meiosis I Cyclin-dependent Protein Serine/threonine Kinase Activity Centriole Assembly Cyclin Binding	Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Magnesium Ion Homeostasis Axonal Growth Cone Chaperone-mediated Protein Complex Assembly RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Telomere Maintenance Via Telomerase Histone Deacetylase Binding Disordered Domain Specific Binding DNA Polymerase Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Tyrosine Kinase Binding Tau Protein Binding CTP Binding DATP Binding Cellular Response To Heat Hypochlorous Acid Biosynthetic Process Protein Folding Chaperone Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation Double-stranded RNA Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Response To Gold Nanoparticle U2-type Post-mRNA Release Spliceosomal Complex Response To Alkaloid DNA Biosynthetic Process Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding Chromosome Organization Response To Heat Neuronal Cell Body Response To Transition Metal Nanoparticle Leading Edge Of Lamellipodium ATP Hydrolysis Activity Telomere Maintenance Melanosome Phagocytic Vesicle Lumen Rab-protein Geranylgeranyltransferase Complex
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