CNNM1 and PTP4A1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology, two hybrid, affinity chromatography technology)

		CNNM1	PTP4A1
Description		cyclin and CBS domain divalent metal cation transport mediator 1	protein tyrosine phosphatase 4A1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Neuronal Cell Body	Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Spindle Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Monoatomic Ion Transport Magnesium Ion Homeostasis Transmembrane Transport	Positive Regulation Of Cell Migration
Pathways
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010 33339817) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 22412388) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954)	Asthma ( 34103634) Schizophrenia ( 28991256)
Interacting Genes		3 interacting genes: HSF2BP PTP4A1 PTP4A2	7 interacting genes: APP ATF7 CNNM1 CREB3L2 GNL1 TUBA1B ZNF212
Entrez ID		26507	7803
HPRD ID		07417	03349
Ensembl ID		ENSG00000119946	ENSG00000112245
Uniprot IDs		A0A8Q3SIV9 B4DKF7 B7Z5S3 Q9NRU3	Q93096
PDB IDs			1RXD 1XM2 5BX1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chromatin Organization Y Chromosome Endosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity X Chromosome Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Protection From Non-homologous End Joining At Telomere Female Meiosis I Regulation Of Heterochromatin Formation Early Endosome Double-strand Break Repair Involved In Meiotic Recombination DNA-templated Transcription Telomere Maintenance In Response To DNA Damage Mitotic G1/S Transition Checkpoint Signaling Cellular Response To Nitric Oxide Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of DNA-templated DNA Replication Cellular Response To Reactive Nitrogen Species Centrosome Duplication Female Meiotic Nuclear Division Response To Nitric Oxide DNA Repair Centriole Replication Regulation Of Chromatin Organization Male Meiosis I Cyclin-dependent Protein Serine/threonine Kinase Activity Centriole Assembly Cyclin Binding	CAMP Response Element Binding Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Dendrite Development Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity General Adaptation Syndrome, Behavioral Process Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of RNA Biosynthetic Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Locomotory Behavior Positive Regulation Of DNA-templated Transcription Structural Molecule Activity Cytoskeleton-dependent Intracellular Transport Axon Choice Point Recognition Positive Regulation Of RNA Metabolic Process Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion
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