KLB

Description		klotho beta
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Fibroblast Growth Factor Receptor Binding Protein Binding Fibroblast Growth Factor Binding
	Biological Process	Carbohydrate Metabolic Process Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Alcohol consumption ( 28937693 27911795 31358974) Alcohol consumption (drinks per week) ( 28485404 31959922 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder (consumption score) ( 33861876 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Asthma ( 30929738) Asthma (adult onset) ( 30929738) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: FGF21 FGFR1
Entrez ID		152831
HPRD ID		14097
Ensembl ID		ENSG00000134962
Uniprot IDs		B4DYH5 Q86Z14
PDB IDs		5VAK 5VAN 5VAQ 5WI9 6NFJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Receptor-receptor Interaction Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Diphosphate Metabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Orbitofrontal Cortex Development Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Phospholipase Activity Regulation Of Lateral Mesodermal Cell Fate Specification Vitamin D3 Metabolic Process Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis Outer Ear Morphogenesis Positive Regulation Of Lipase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Mesodermal Cell Differentiation Mesenchymal-epithelial Cell Signaling Positive Regulation Of MAPK Cascade Cementum Mineralization Fibroblast Growth Factor Receptor Activity Auditory Receptor Cell Development Paraxial Mesoderm Development Response To Sodium Phosphate Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Phosphate Transport Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Salivary Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cell-cell Signaling Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Nuclear Cell Cycle DNA Replication Vitamin D Metabolic Process Inner Ear Receptor Cell Development Ear Development Regulation Of MAPK Cascade Signaling Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of DNA-templated DNA Replication Regulation Of Postsynaptic Density Assembly Middle Ear Morphogenesis Tooth Mineralization Positive Regulation Of Transport
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