KLB and FGF21

Number of citations of the paper that reports this interaction (PMID 19059246)
17

Data Source:
HPRD (in vitro)

		KLB	FGF21
Gene Name		klotho beta	fibroblast growth factor 21
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Fibroblast Growth Factor Receptor Binding Protein Binding Fibroblast Growth Factor Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Carbohydrate Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer betaKlotho-mediated ligand binding Signaling by FGFR Klotho-mediated ligand binding FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Dietary macronutrient intake ( 23372041 23636237) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		1 interactors: FGF21	5 interactors: CDC25A CDH7 KLB MAPK7 NEDD4
Entrez ID		152831	26291
HPRD ID		14097	09447
Ensembl ID		ENSG00000134962	ENSG00000105550
Uniprot IDs		B4DYH5 Q86Z14	Q9NSA1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Receptor Biosynthetic Process Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Receptor Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Glucose Transport Regulation Of Glucose Import Regulation Of Glucose Transport Positive Regulation Of ERK1 And ERK2 Cascade Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To UV Cellular Response To Light Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Response To UV Cellular Response To Radiation Negative Regulation Of CAMP Catabolic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Progesterone Receptor Signaling Pathway Negative Regulation Of NFAT Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Immune Response Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Response To Light Stimulus Regulation Of Phosphorus Metabolic Process Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Transport Protein Localization To Lysosome Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Intracellular Transport Response To Radiation Cellular Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Response To Inorganic Substance Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Receptor Catabolic Process Cellular Response To Organic Substance Single Organismal Cell-cell Adhesion Protein Targeting To Vacuole CAMP-mediated Signaling Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Vacuole Cellular Response To Growth Factor Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Potassium Ion Transmembrane Transporter Activity
Tagcloud ?		5httlpr 7alpha ba cholesten colonic constipation ct48 fdr fecal fgf19 fgfr4 gpbar1 ibs insert irritable multifaceted pathobiological pathobiology predisposing reuptake rs11554825 rs17618244 rs351855 rs4263839 rs4795541 sensation slc6a4 tnfsf15 transit	1alpha 3beta akt1 akt2 ampk blots deletion diabetic exacerbates exacerbating examining fatty fibroblast germ gs gsk inactivated ko maintaining pgc protects reflected sirt1 spermatogenesis streptozotocin testes testicular tried
Tagcloud (Difference) ?		5httlpr 7alpha ba cholesten colonic constipation ct48 fdr fecal fgf19 fgfr4 gpbar1 ibs insert irritable multifaceted pathobiological pathobiology predisposing reuptake rs11554825 rs17618244 rs351855 rs4263839 rs4795541 sensation slc6a4 tnfsf15 transit	1alpha 3beta akt1 akt2 ampk blots deletion diabetic exacerbates exacerbating examining fatty fibroblast germ gs gsk inactivated ko maintaining pgc protects reflected sirt1 spermatogenesis streptozotocin testes testicular tried
Tagcloud (Intersection) ?