GALNT8 and DOLK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GALNT8	DOLK
Description		polypeptide N-acetylgalactosaminyltransferase 8	dolichol kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		O-linked glycosylation of mucins	Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		1 interacting genes: DOLK	21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR
Entrez ID		26290	22845
HPRD ID		09374	15525
Ensembl ID		ENSG00000130035	ENSG00000175283
Uniprot IDs		Q9NY28	A0A0S2Z597 Q9UPQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Dolichol Kinase Activity Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process I-kappaB Phosphorylation Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure IkappaB Kinase Complex Presynaptic Active Zone Organization Presynaptic Active Zone Cytoplasmic Component Isoprenoid Biosynthetic Process Maintenance Of Synapse Structure Podosome Phosphate-containing Compound Metabolic Process Cell Junction Maintenance Glycolipid Biosynthetic Process Cellular Component Maintenance Protein N-linked Glycosylation PDZ Domain Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Retrograde Transport, Endosome To Golgi	Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway
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