AK5 and RNF114

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AK5	RNF114
Gene Name		adenylate kinase 5	ring finger protein 114
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol	Intracellular Nucleus Cytoplasm
	Molecular Function	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding Nucleoside Kinase Activity	Zinc Ion Binding Ligase Activity
	Biological Process	Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process DADP Biosynthetic Process Nucleoside Triphosphate Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process ATP Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Multicellular Organismal Development Spermatogenesis Protein Ubiquitination Cell Differentiation
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS			Psoriasis ( 20953189)
Protein-Protein Interactions		7 interactors: C7orf26 CPNE6 NUCKS1 RNF114 STRN4 TRIM46 UGDH	26 interactors: AK5 BMI1 EVI2A MAPK3 RNF38 RPSA TRAF4 TRAF6 TRAIP TRIM52 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W UEVLD XAF1
Entrez ID		26289	55905
HPRD ID		10472	10329
Ensembl ID		ENSG00000154027	ENSG00000124226
Uniprot IDs		Q9Y6K8	Q9Y508
PDB IDs		2BWJ
Enriched GO Terms of Interacting Partners?		UDP-glucuronate Biosynthetic Process UDP-glucuronate Metabolic Process	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Regulation Of Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Ligase Activity Cellular Response To Stress Proteolysis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Apoptotic Process Cellular Response To Oxygen Levels Programmed Cell Death Histone Ubiquitination Catabolic Process Immune Response-regulating Signaling Pathway Cell Death Death Protein Monoubiquitination Innate Immune Response
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