SACS and CD83

		SACS	CD83
Description		sacsin molecular chaperone	CD83 molecule
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Hsp70 Protein Binding Identical Protein Binding Low-density Lipoprotein Particle Receptor Binding Protein-folding Chaperone Binding Proteasome Binding	Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Inclusion Body Assembly	Immune System Process Defense Response Humoral Immune Response Signal Transduction Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)	Breast cancer and/or colorectal cancer ( 29698419) California verbal learning test score ( 31596458) Chronotype ( 30696823) Obesity-related traits ( 23251661) Response to tofacitinib treatment (herpes zoster) ( 33455090) Response to tofacitinib treatment (herpes zoster)(time to event) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Rheumatoid arthritis ( 22446963 24390342 30423114)
Interacting Genes		7 interacting genes: ACTN4 ADRB2 DSCAM PICK1 POLR1H TSC22D4 UBE3A	2 interacting genes: EIF4E FATE1
Entrez ID		26278	9308
HPRD ID		05135	05170
Ensembl ID		ENSG00000151835	ENSG00000112149
Uniprot IDs		A0A804HIQ1 Q9NZJ4	A0A087WX61 Q01151
PDB IDs		1IUR 3O10 5V44 5V45 5V46 5VSX 5VSZ	5MIX 5MJ0 5MJ1 5MJ2
Enriched GO Terms of Interacting Partners?		Nucleoside Binding Positive Regulation Of Sodium:proton Antiporter Activity Nuclear Receptor-mediated Signaling Pathway Regulation Of Sodium Ion Transport Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Modulation Of Chemical Synaptic Transmission Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Sperm Entry Regulation Of Golgi Lumen Acidification Positive Regulation Of Golgi Lumen Acidification Termination Of RNA Polymerase I Transcription	Eukaryotic Initiation Factor 4G Binding GMP Reductase Activity GMP Reductase Complex Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Estradiol Secretion
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