LCE2B and VASN

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE2B	VASN
Description		late cornified envelope 2B	vasorin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Mitochondrion Lysosomal Membrane Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Signaling Receptor Activity Cadherin Binding Transforming Growth Factor Beta Binding
	Biological Process	Epidermis Development Keratinization	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Hypoxia Cellular Response To Redox State
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	A body shape index ( 34021172) Erectile dysfunction ( 30583798) Hip circumference adjusted for BMI ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		78 interacting genes: ADAMTSL4 CRCT1 CYSRT1 DHRS1 GRN GUCD1 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE4A LCE5A MDFI NBPF19 NECTIN2 NOTCH2NLA NR4A3 NUFIP2 OTX1 PLA2G10 PLAC8 PLSCR3 PLSCR4 RGS17 RGS20 RNF4 SPRED2 SPRY3 TGFB1 TRIM42 TSPAN4 VASN	66 interacting genes: ADAMTSL4 AQP3 CFTR CIB4 CYSRT1 GRN GUCD1 HOXA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-4 KRTAP5-6 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE4A LCE5A LNX1 MDFI MEOX2 MTUS2 NBPF19 NOTCH2NLA NR4A3 RGS17 RGS19 RGS20 RNF31 SMCP SSC4D TGFB1 TGFB2 TGFB3 TGM1 TRIP6 VWC2
Entrez ID		26239	114990
HPRD ID		17260	10587
Ensembl ID		ENSG00000159455	ENSG00000168140
Uniprot IDs		O14633	Q6EMK4
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Cytosol	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Type III Transforming Growth Factor Beta Receptor Binding Hair Cycle Identical Protein Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Uterine Wall Breakdown Protein Binding Transforming Growth Factor Beta Receptor Binding Odontogenesis Gland Morphogenesis Face Morphogenesis Regulation Of Enamel Mineralization Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Interstitial Matrix Regulation Of Macrophage Cytokine Production Positive Regulation Of SMAD Protein Signal Transduction Structural Molecule Activity Type I Transforming Growth Factor Beta Receptor Binding
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