TOR1AIP1 and GPR161

		TOR1AIP1	GPR161
Description		torsin 1A interacting protein 1	G protein-coupled receptor 161
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Endomembrane System Membrane Nuclear Membrane	Plasma Membrane Cilium Membrane Endocytic Vesicle Membrane Cell Projection Recycling Endosome Ciliary Membrane
	Molecular Function	ATPase Activator Activity Protein Binding Lamin Binding Cytoskeletal Protein Binding ATPase Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Positive Regulation Of ATP-dependent Activity Protein Localization To Nucleus Nuclear Membrane Organization Protein Localization To Nuclear Envelope	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways		RHOD GTPase cycle RHOF GTPase cycle	Hedgehog 'off' state Hedgehog 'on' state
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Red cell distribution width ( 27863252)
Interacting Genes		8 interacting genes: CDC42 LMNA LMNB1 OGT PPP1CA PPP1CC TERF2 TERF2IP	8 interacting genes: CCR2 CLDN19 COMT CREBBP EFNA5 GPR35 SLC30A2 UPK1B
Entrez ID		26092	23432
HPRD ID		13958	17070
Ensembl ID		ENSG00000143337	ENSG00000143147
Uniprot IDs		Q5JTV8	A0A0A0MQW8 Q8N6U8
PDB IDs		4TVS	8KH4 8SMV
Enriched GO Terms of Interacting Partners?		Telomere Maintenance In Response To DNA Damage Organelle Organization Structural Constituent Of Nuclear Lamina Negative Regulation Of DNA Recombination At Telomere Nuclear Migration Nucleus Localization Chromosome, Telomeric Region Lamin Filament Nuclear Pore Localization Shelterin Complex Postsynapse Circadian Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Protection From Non-homologous End Joining At Telomere Glutamatergic Synapse Intracellular Protein Localization Establishment Of Organelle Localization Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Protein Localization To Organelle Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of Cellular Component Organization Nuclear Lamina Telomere Maintenance Protein Localization To Nuclear Envelope Regulation Of Telomere Maintenance Chromosome Organization Telomere Organization Circadian Rhythm Nuclear Envelope Organization Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding RNA-templated DNA Biosynthetic Process Organelle Localization Transport Along Microtubule Photoperiodism Entrainment Of Circadian Clock Telomeric DNA Binding Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Telomere Maintenance Microtubule-based Transport Intracellular Transport Regulation Of Chromosome Organization Rhythmic Process Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Glycogen Metabolic Process Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination	Norepinephrine Secretion Renal Absorption Catechol O-methyltransferase Activity Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Chemokine Receptor Activity Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Cellular Response To Phosphate Starvation Regulation Of Biological Quality Histone H3K27 Acetyltransferase Activity Chemokine-mediated Signaling Pathway Mesaxon Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Renal System Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Cell-cell Adhesion Apical Plasma Membrane Urothelial Plaque Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Regulation Of Transepithelial Transport CCR2 Chemokine Receptor Binding Regulation Of Thymocyte Migration Positive Regulation Of T Cell Extravasation Regulation Of Immune Complex Clearance By Monocytes And Macrophages Cerebellar Cortex Morphogenesis MRF Binding Zinc:proton Antiporter Activity Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Positive Regulation Of Cytosolic Calcium Ion Concentration Dopamine Secretion
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