GIGYF2 and METTL21A

		GIGYF2	METTL21A
Description		GRB10 interacting GYF protein 2	methyltransferase 21A, HSPA lysine
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GO Annotations	Cellular Component	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Vesicle Protein-containing Complex Perikaryon Proximal Dendrite	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Cadherin Binding Molecular Adaptor Activity Proline-rich Region Binding	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding
	Biological Process	Feeding Behavior Adult Locomotory Behavior Post-embryonic Development Post-transcriptional Gene Silencing Negative Regulation Of Translation Spinal Cord Motor Neuron Differentiation Mitotic G1 DNA Damage Checkpoint Signaling Multicellular Organism Growth Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuromuscular Process Controlling Balance Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Rescue Of Stalled Ribosome	Protein Methylation Methylation Negative Regulation Of Protein Folding
Pathways			Protein methylation
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Anxiety and stress-related disorders ( 31116379) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Schizophrenia ( 23974872 25056061 29483656)	HDL cholesterol levels ( 32203549) Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)
Interacting Genes		12 interacting genes: APC CNOT9 CRYAA GRB10 GRB14 GRB7 RBM12 RNF10 SNRPB UBC USP7 WBP11	14 interacting genes: ARPC4 ATRIP FAM200C HSPA1A HSPA5 LNX1 LZTS1 MEI4 MEOX2 MSRB3 PFDN5 ZNF620 ZNF655 ZRANB1
Entrez ID		26058	151194
HPRD ID		11639	14090
Ensembl ID		ENSG00000204120	ENSG00000144401
Uniprot IDs		Q6Y7W6	C9JES0 H7BXH9 Q8WXB1
PDB IDs		5NVL 5NVM 7RUP	4LEC
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Lens Fiber Cell Morphogenesis Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Leading Edge Membrane Cytosol Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Protein Methylation
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