LRRTM2 and TMEM120B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRTM2	TMEM120B
Description		leucine rich repeat transmembrane neuronal 2	transmembrane protein 120B
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane	Nucleus Nuclear Inner Membrane Membrane
	Molecular Function	Protein Binding Neurexin Family Protein Binding	Monoatomic Ion Channel Activity Protein Binding
	Biological Process	Negative Regulation Of Receptor Internalization Synapse Organization Positive Regulation Of Synapse Assembly Long-term Synaptic Potentiation Regulation Of Postsynaptic Density Assembly	Fat Cell Differentiation Protein Heterooligomerization
Pathways		Neurexins and neuroligins
Drugs
Diseases
GWAS		Malaria ( 31844061)	HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 27863252 32888494) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: TMEM120B TNF	59 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 ARL13B BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 HSD17B13 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 SLC35H1 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15
Entrez ID		26045	144404
HPRD ID		17454	19119
Ensembl ID		ENSG00000146006	ENSG00000188735
Uniprot IDs		O43300	A0PK00
PDB IDs		5Z8X 5Z8Y	7F73
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Chronic Inflammatory Response To Antigenic Stimulus Response To Gram-negative Bacterium Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Positive Regulation Of Vitamin D Biosynthetic Process Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Positive Regulation Of Neutrophil Activation Response To Transition Metal Nanoparticle Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Chronic Inflammatory Response Regulation Of Bile Acid Secretion Death Receptor Agonist Activity Response To Isolation Stress Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Negative Regulation Of Bicellular Tight Junction Assembly Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Vascular Endothelial Growth Factor Production Positive Regulation Of Fever Generation Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Branching Involved In Salivary Gland Morphogenesis Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Podosome Assembly Response To Macrophage Colony-stimulating Factor Negative Regulation Of Amyloid-beta Clearance Chronic Inflammatory Response Response To Fructose Endothelial Cell Apoptotic Process Positive Regulation Of Action Potential Regulation Of Neutrophil Activation Necroptotic Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Fever Generation Cellular Response To Nicotine Negative Regulation Of Cellular Respiration Positive Regulation Of Heat Generation Positive Regulation Of Interleukin-18 Production Negative Regulation Of Myelination Negative Regulation Of Vascular Wound Healing Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Oxidative Phosphorylation	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Organic Hydroxy Compound Transport Steroid Dehydrogenase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Transmembrane Transport Monoamine Transport Leukocyte Mediated Immunity Gamma-aminobutyric Acid Biosynthetic Process Prostanoid Metabolic Process Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Transport Norepinephrine Transport Gamma-aminobutyric Acid Metabolic Process Icosanoid Metabolic Process Ammonium Channel Activity Neurotransmitter Transport Symporter Activity Icosanoid Biosynthetic Process Ammonium Transmembrane Transport Cellular Response To Cocaine Cellular Detoxification Negative Regulation Of Peptide Secretion Amine Transport Cytokine Receptor Activity Serotonin Transport L-glutamate Transmembrane Transporter Activity Lymphocyte Mediated Immunity Non-motile Cilium Assembly Nuclear Envelope Water Channel Activity Negative Regulation Of Leukocyte Apoptotic Process
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