RPL36 and SHC2

		RPL36	SHC2
Description		ribosomal protein L36	SHC adaptor protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Ribonucleoprotein Complex	Cytosol Plasma Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Cytoplasmic Translation Translation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		4 interacting genes: APP DUX4 PTEN RPL18A	12 interacting genes: EGFR ERBB2 ERBB3 ERBB4 FLT1 GRB2 KDR KIT MET NTRK1 NTRK2 NTRK3
Entrez ID		25873	25759
HPRD ID		10201	19296
Ensembl ID		ENSG00000130255	ENSG00000129946
Uniprot IDs		Q9Y3U8	P98077
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QGG 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Ruffle Membrane Negative Regulation Of Cell Population Proliferation Cell Projection Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Reproductive Process Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Modulation Of Excitatory Postsynaptic Potential Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Reproductive Behavior Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Phagosome Membrane Cold Acclimation	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Neuron Differentiation ATP Binding Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Growth Factor Binding Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Nucleotide Binding Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Protein Phosphorylation ERBB Signaling Pathway Phosphorylation Regulation Of Programmed Cell Death Cellular Developmental Process Myelination Axon Ensheathment Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Communication Regulation Of Signaling Cell Development Positive Regulation Of Phosphate Metabolic Process
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