TMEM31 and MS4A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM31	MS4A1
Description		transmembrane protein 31	membrane spanning 4-domains A1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Space Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Immunoglobulin Binding MHC Class II Protein Complex Binding Identical Protein Binding
	Biological Process		Store-operated Calcium Entry Humoral Immune Response Cell Surface Receptor Signaling Pathway Response To Bacterium B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway Protein Tetramerization Calcium Ion Import Into Cytosol Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways
Drugs			Rituximab Ibritumomab tiuxetan Tositumomab Ofatumumab Obinutuzumab Technetium Tc-99m nofetumomab merpentan Ublituximab Ocrelizumab Mosunetuzumab Odronextamab
Diseases
GWAS			Recurrent major depressive disorder ( 29317602)
Interacting Genes		138 interacting genes: ABHD16A ABHD5 AGPAT4 AGTRAP ANKRD46 APOD ARV1 ATP6V0C BCAP31 BLCAP BMP10 BNIP1 BTN2A2 C14orf180 C2CD2L CAMLG CCL4 CGRRF1 CLDND2 CLN5 CLRN1 CMTM7 CNIH3 COX14 COX20 CTSA CTXN3 CXCL9 CXorf66 CYB561A3 CYB5R3 DEFB103A DEFB103B DEFB105A DEFB105B DERL1 DERL3 DGAT2L6 DHRSX DNAJC30 EBP EHHADH EMP1 ERG28 FAXDC2 FCER1G FKBP8 FXYD6 GIMAP5 GJB2 GJD4 GPR151 GUCA2A GYPA HERPUD2 HIGD1C HSD17B13 HSD3B7 IFITM5 ITGAM LHFPL5 LPAR3 LRAT LY6D MALL MMP14 MS4A1 NAT8 NINJ1 NINJ2 NSDHL ORMDL2 OTOP3 OTULINL PEDS1-UBE2V1 PLN PLP1 PLP2 PMP22 PNLIPRP1 PTPN1 RDH11 REEP2 RETREG3 RNF144A RNF19B RTP2 SELENOK SELENOM SERP2 SGTA SLC30A8 SLC35E4 SLC35H1 SLC39A6 SLC41A1 SLC66A2 SLC71A2 SLC7A14 SMAGP SMIM1 SMIM3 SMPD2 SNORC SPTSSA STX12 STX5 SYNGR1 TEX264 TIMMDC1 TMBIM6 TMEM107 TMEM121 TMEM14A TMEM14C TMEM182 TMEM203 TMEM208 TMEM218 TMEM239 TMEM242 TMEM254 TMEM255B TMEM44 TMEM50A TMEM86A TMX2 TNFRSF10B TRARG1 TSPAN2 TVP23B UBE2J1 VAMP2 VAMP3 VAMP5 YIF1A YIPF6 ZFPL1	41 interacting genes: ACKR2 AQP6 CD40 CERS4 CLEC14A CREB3 CREB3L1 CSNK2A1 CSNK2A2 FAM209A FCRL3 FYN GORAB GPR42 HSD17B11 HSD17B13 IL7R KASH5 LCK LEUTX LMNA LYN MDM2 MMD MTIF3 REEP2 REEP4 RNF19B RNF5 SLC10A1 SLC10A6 SLC18A1 SLC35H1 SLC71A2 THAP4 TMEM31 TMEM72 TMEM82 TMPPE TMX2 TSPO2
Entrez ID		203562	931
HPRD ID		06652	00204
Ensembl ID		ENSG00000179363	ENSG00000156738
Uniprot IDs		A0A140VK58 Q5JXX7	P11836
PDB IDs			2OSL 3BKY 3PP4 6VJA 6Y90 6Y92 6Y97 6Y9A 8VGN 8VGO
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Sterol Biosynthetic Process Lipid Biosynthetic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process SNAP Receptor Activity Lipid Droplet Lipid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Bleb Assembly Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Mitochondrial Membrane Regulation Of Retrograde Protein Transport, ER To Cytosol Organelle Membrane Fusion Cholesterol Biosynthetic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Establishment Of Protein Localization To Membrane Regulation Of Cellular Localization Regulation Of Intracellular Transport Membrane Destabilizing Activity Cellular Response To Unfolded Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Sterol Metabolic Process Mitochondrial Respiratory Chain Complex Assembly Organelle Fusion Response To Unfolded Protein Regulation Of Protein Exit From Endoplasmic Reticulum Membrane Organization	Membrane Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Protein Kinase CK2 Complex Steroid Dehydrogenase Activity CD8 Receptor Binding Bile Acid:sodium Symporter Activity Fc-gamma Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lymphocyte Activation Lymphocyte Proliferation Mononuclear Cell Proliferation B Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Costimulation CD4 Receptor Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Peptidyl-tyrosine Phosphorylation Monocarboxylic Acid Transport Phospholipase Activator Activity Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Activation Fc Receptor Signaling Pathway Leukocyte Proliferation T Cell Receptor Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of B Cell Proliferation Organic Hydroxy Compound Transport Protein Binding Response To Xenobiotic Stimulus Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Adaptive Immune Response Phosphatidylinositol 3-kinase Binding Negative Regulation Of Apoptotic Process Transmembrane Transport Protein Kinase Activity Negative Regulation Of Programmed Cell Death Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Bile Acid And Bile Salt Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Lymphocyte Activation Nuclear Envelope Organization
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