SUN2 and RASD2

		SUN2	RASD2
Description		Sad1 and UNC84 domain containing 2	RASD family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Nuclear Envelope Nuclear Inner Membrane Endosome Endosome Membrane Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Plasma Membrane Membrane Synapse
	Molecular Function	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein-membrane Adaptor Activity Cytoskeleton-nuclear Membrane Anchor Activity	Nucleotide Binding GTPase Activity GTP Binding G-protein Beta-subunit Binding
	Biological Process	Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Nuclear Matrix Anchoring At Nuclear Membrane	Synaptic Transmission, Dopaminergic Signal Transduction Locomotory Behavior Positive Regulation Of Protein Sumoylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Meiotic synapsis
Drugs
Diseases
GWAS		Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Chronotype ( 30696823) Hippocampal volume in mild cognitive impairment ( 29274321) Intelligence (MTAG) ( 29326435) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: HGS NRM PRPF6 RAB5B RPS20 SRSF10	16 interacting genes: ACVR1 BMPR1B GNB1 GNB2 GNB3 PIK3CA PIK3R1 RABAC1 RAF1 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SMURF2 TGFBR1
Entrez ID		25777	23551
HPRD ID		15611	15210
Ensembl ID		ENSG00000100242	ENSG00000100302
Uniprot IDs		B0QY60 B0QY64 B4E2A6 Q9UH99	Q96D21
PDB IDs		3UNP 4DXR 4DXS 4DXT 4FI9 6WMD 6WME 6WMF 6WMG
Enriched GO Terms of Interacting Partners?		Endosome Organization Spliceosomal Tri-snRNP Complex Assembly	I-SMAD Binding SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Heteromeric SMAD Protein Complex Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I SMAD Protein Signal Transduction Response To Growth Factor Regulation Of Developmental Process R-SMAD Binding BMP Signaling Pathway Intracellular Glucose Homeostasis Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Trophoblast Cell Migration Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway GTPase Binding Pattern Specification Process Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Extracellular Matrix Assembly Gastrulation Osteoblast Differentiation Ameboidal-type Cell Migration Tissue Development Regionalization Transmembrane Receptor Protein Serine/threonine Kinase Activity Co-SMAD Binding Cellular Response To Growth Factor Stimulus Primary MiRNA Processing Embryonic Pattern Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Signal Transduction Regulation Of SMAD Protein Signal Transduction Intracellular Signaling Cassette Response To Transforming Growth Factor Beta Cell Fate Commitment Positive Regulation Of Cell Differentiation Regulation Of Cartilage Development Positive Regulation Of Multicellular Organismal Process Homomeric SMAD Protein Complex Glucose Homeostasis
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