H2AP and CENPH

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		H2AP	CENPH
Description		H2A.P histone	centromere protein H
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol
	Molecular Function	Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Protein Binding Kinetochore Binding
	Biological Process	Heterochromatin Formation	Mitotic Spindle Organization Chromosome Segregation Kinetochore Assembly Kinetochore Organization
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: ATXN1 CENPH CEP44 HTT MAGEB4 MYOG NTAQ1 SEPTIN10 ZDHHC17	19 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 CRYAA DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NUF2 NUP54 RASSF4 SPAG5 UBC ZNF493 ZSCAN12
Entrez ID		25763	64946
HPRD ID		19386	12029
Ensembl ID		ENSG00000187516	ENSG00000153044
Uniprot IDs		O75409	A0A0S2Z5T0 Q9H3R5
PDB IDs			7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?			Lens Fiber Cell Morphogenesis Kinetochore Nuclear Chromosome Segregation Cytoskeleton Organization Protein Localization To Nuclear Envelope Microtubule Cytoskeleton Organization Nucleus Organization Microtubule-based Process Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Centrosome Microtubule Plus-end Chromosome Segregation Organelle Organization Spindle Organization Chromosome, Centromeric Region Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Cell Morphogenesis Nucleoside Metabolic Process Midbody S-methyl-5-thioadenosine Phosphorylase Activity Mitotic Metaphase Chromosome Alignment Protein Localization To Cytoskeleton Organelle Localization Structural Constituent Of Nuclear Lamina Nicotinamide Riboside Catabolic Process Zonula Adherens Assembly Metaphase Chromosome Alignment Regulation Of Cellular Localization Microtubule Binding Establishment Of Organelle Localization Protein Localization To Nuclear Inner Membrane
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