LYSMD2 and DUSP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LYSMD2	DUSP4
Description		LysM domain containing 2	dual specificity phosphatase 4
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Serine/threonine Phosphatase Activity
	Biological Process		Endoderm Formation Signal Transduction Dephosphorylation Negative Regulation Of MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways			RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway
Drugs
Diseases
GWAS			Gestational age at birth (maternal effect) ( 28598419) Postoperative complication after cardiac surgery ( 30678657) Prostate cancer ( 33293427) Response to statin therapy ( 20339536) Spontaneous preterm birth (maternal effect) ( 28598419)
Interacting Genes		3 interacting genes: CEP19 DUSP4 LCN9	19 interacting genes: APP CRMP1 GORASP2 GRIN1 GRIN2D LYSMD1 LYSMD2 LZTS2 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 NOXA1 PLEKHF2 TEPSIN TRAF1 ZNF426 ZNF655
Entrez ID		256586	1846
HPRD ID		17531	04123
Ensembl ID		ENSG00000140280	ENSG00000120875
Uniprot IDs		Q8IV50	Q13115
PDB IDs			3EZZ
Enriched GO Terms of Interacting Partners?		MAP Kinase Serine/threonine Phosphatase Activity Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Vesicle Targeting, To, From Or Within Golgi MAP Kinase Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Endoderm Formation Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Vesicle Targeting Microtubule Anchoring Small Molecule Binding	MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cyclase Activity Intracellular Signaling Cassette Interleukin-34-mediated Signaling Pathway JUN Kinase Activity Ionotropic Glutamate Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential MAPK Cascade Regulation Of Golgi Inheritance Lipopolysaccharide-mediated Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Ligand-gated Ion Channel Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Response To Lipopolysaccharide NMDA Glutamate Receptor Activity Glutamate Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Inflammatory Response Response To Molecule Of Bacterial Origin NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Protein Serine Kinase Activity Cellular Response To Amino Acid Starvation Glial Cell Development Cellular Senescence Excitatory Chemical Synaptic Transmission Bergmann Glial Cell Differentiation Response To Amino Acid Starvation Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Mechanical Stimulus Regulation Of Immune Response Regulation Of Synaptic Plasticity Protein Serine/threonine Kinase Activity Neuron Projection Maintenance
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