GABRA2 and GABRG2

Number of citations of the paper that reports this interaction (PubMedID 31080408)
91

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GABRA2	GABRG2
Description		gamma-aminobutyric acid type A receptor subunit alpha2	gamma-aminobutyric acid type A receptor subunit gamma2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Cell Projection Neuronal Cell Body Synapse Postsynaptic Membrane Inhibitory Synapse Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex	Plasma Membrane Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Post-embryonic Development Adult Behavior Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		GABA receptor activation GABA receptor activation	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Zopiclone Flumazenil Estazolam Estazolam Sevoflurane Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Pagoclone Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone AZD-7325 Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam	Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Alprazolam Zolpidem Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam Muscimol 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Adventurousness ( 30643258) Epilepsy ( 25087078) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Systolic blood pressure ( 30224653)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cognitive decline rate in late mild cognitive impairment ( 26252872) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Nicotine dependence symptom count ( 25555482) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		2 interacting genes: GABRG2 UBQLN1	8 interacting genes: CFTR DRD5 GABARAP GABRA2 PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		2555	2566
HPRD ID		11747	00663
Ensembl ID		ENSG00000151834	ENSG00000113327
Uniprot IDs		E9PBQ7 G5E9Z6 P47869	A0A1W2PQR9 A0A1W2PR49 A0A1W2PRN4 A0A1X7SBZ8 A8MWU7 P18507
PDB IDs		9CRV 9CSB 9CT0 9CTJ 9CTV 9CX7 9CXB 9CXC	6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7QNB 7QNE 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CX7 9CXA 9CXB 9CXC 9CXD 9DRX 9EQG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Store-operated Calcium Channel Activity Cytoplasmic Vesicle GABA-A Receptor Activity Cellular Response To Histamine GABA-A Receptor Complex Response To Histamine Inhibitory Synapse Assembly Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Aggrephagy Positive Regulation Of ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Transporter Activity Regulation Of ERAD Pathway Postsynaptic Specialization Membrane Dendrite Membrane Synaptic Transmission, GABAergic Aggresome Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Chloride Channel Complex Negative Regulation Of Calcium Ion Transport Autophagosome Maturation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Proteasome Complex Chloride Channel Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Post-embryonic Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Synapse Assembly GABA-ergic Synapse Autophagosome Kinase Binding Regulation Of Transmembrane Transporter Activity Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Organization Autophagosome Assembly Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway ERAD Pathway Negative Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Chloride Transport	Positive Regulation Of Angiotensin-activated Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Regulation Of Exocytosis Positive Regulation Of Protein Localization Regulation Of Protein Localization Protein Kinase C Signaling Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Exocytosis Positive Regulation Of Insulin Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Mitotic Nuclear Membrane Disassembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Nuclear Membrane Disassembly Membrane Disassembly Diacylglycerol-dependent Serine/threonine Kinase Activity Monoatomic Ion Transport Regulation Of Biological Quality Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Renal Sodium Ion Absorption Regulation Of G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Regulation Of Insulin Secretion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Receptor Localization To Synapse Regulation Of Vesicle-mediated Transport Regulation Of Peptide Hormone Secretion Regulation Of Secretion By Cell Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Secretion Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Synaptic Vesicle Exocytosis Nuclear Membrane Organization Chloride Channel Complex Regulation Of Cell Communication Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity
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